DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and ZNF57

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_775751.1	Gene:	ZNF57 / 126295	HGNCID:	13125	Length:	555	Species:	Homo sapiens

Alignment Length:	408	Identity:	91/408 - (22%)
Similarity:	137/408 - (33%)	Gaps:	109/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GKRKKPAELELTCGWRDCQEICTGEWSLNGH--------------IGD------HLEHYAKAQDD 59
            |::..|.|        :|::.|.....|:.|              .|.      :|.|:.|
Human   164 GRKAPPGE--------ECKQACICPSHLHSHGRTDTEEKPYKCQACGQTFQHPRYLSHHVK---- 216

  Fly    60 RGAHAEHTEHQCTWNSCDFRTENQVEFERHSYYHGYYLNLLLQGKLECDLHPEIPACTAPARLME 124
              .|.....::|  ..|.........|.||...|
Human   217 --THTAEKTYKC--EQCRMAFNGFASFTRHVRTH------------------------------- 246

  Fly   125 KLPALGQNFRCGWTDCEREFVSIVEFQDHIVKHA------------LFEYD-----IQKTPEDER 172
               ...:.::|  .:|.|.|:....||.|:..|.            .|.|.     .:||...|:
Human   247 ---TKDRPYKC--QECGRAFIYPSTFQRHMTTHTGEKPYKCQHCGKAFTYPQAFQRHEKTHTGEK 306

  Fly   173 PKTMCNWAMCHKHMGNKYRLIEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQC 237
            |.. |.  .|.|.......|..|:..|:..|...|.|||:.|.:..:...|||  .......::|
Human   307 PYE-CK--QCGKTFSWSETLRVHMRIHTGDKLYKCEHCGKAFTSSRSFQGHLR--THTGEKPYEC 366

  Fly   238 AQCFKFFATKKLLKSHVVRHV--NCYKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCV 300
            .||.|.|......:.||..|.  ..|||..|....:|:.|...|:| .|..:||.:|.:|.....
Human   367 KQCGKAFTWSSTFREHVRIHTQEQLYKCEQCGKAFTSSRSFRGHLR-THTGEKPYECKQCGKTFT 430

  Fly   301 RESDLAKHVQIVHSKTVHQCEHPDCHYSVRTYTQMRRHFLEVH-GNNPILYACHCCERFFKSGKS 364
            ..|...:||:|...:.:|:|||  |..:..:....:.| |.:| |..|  |.|..|.:.|....:
Human   431 WSSTFREHVRIHTQEQLHKCEH--CGKAFTSSRAFQGH-LRMHTGEKP--YECKQCGKTFTWSST 490

  Fly   365 LSAHLMKKHGFRLPSGHK 382
            |..|:      |:.:|.|
Human   491 LHNHV------RMHTGEK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	4/16 (25%)
		C2H2 Zn finger	207..225	CDD:275368	6/17 (35%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..311	CDD:275368	5/18 (28%)
		C2H2 Zn finger	352..373	CDD:275368	5/20 (25%)
ZNF57	NP_775751.1	KRAB	4..>44	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	118..134	CDD:275368
		COG5048	138..546	CDD:227381	91/408 (22%)
		C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	171..190	CDD:275368	5/26 (19%)
		C2H2 Zn finger	198..218	CDD:275368	4/25 (16%)
		C2H2 Zn finger	226..246	CDD:275368	5/21 (24%)
		C2H2 Zn finger	254..274	CDD:275368	7/21 (33%)
		zf-H2C2_2	267..291	CDD:290200	5/23 (22%)
		C2H2 Zn finger	282..302	CDD:275368	3/19 (16%)
		zf-H2C2_2	294..318	CDD:290200	7/26 (27%)
		C2H2 Zn finger	310..330	CDD:275368	5/21 (24%)
		zf-H2C2_2	323..347	CDD:290200	9/23 (39%)
		C2H2 Zn finger	338..358	CDD:275368	8/21 (38%)
		zf-H2C2_2	350..374	CDD:290200	7/25 (28%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	6/20 (30%)
		zf-H2C2_2	406..430	CDD:290200	8/24 (33%)
		C2H2 Zn finger	422..442	CDD:275368	5/19 (26%)
		C2H2 Zn finger	450..470	CDD:275368	6/22 (27%)
		zf-H2C2_2	466..486	CDD:290200	8/22 (36%)
		C2H2 Zn finger	478..498	CDD:275368	6/25 (24%)
		C2H2 Zn finger	506..526	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910