DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17829 and ZNF268

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	253	Identity:	76/253 - (30%)
Similarity:	108/253 - (42%)	Gaps:	51/253 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 DCEREFVSIVEFQDHIVKHALFEYDIQKTPEDERPKTMCNWAMCHKHMGNKYRLIEHISTHSNKK 203
            :|.:.|    .|...::.|       |:....|.|.. |  :.|.|....|.:||.|..||:.:|
Human   728 ECGKSF----SFNSQLIVH-------QRIHTGENPYE-C--SECGKAFNRKDQLISHQRTHAGEK 778

  Fly   204 QVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRH--VNCYKCTMC 266
            ...|..||:.|.:|:.|..|:|  ..:....::|.:|.|.|..|.||..|...|  ||.|||:.|
Human   779 PYGCSECGKAFSSKSYLIIHMR--THSGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQC 841

  Fly   267 DMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHP-DCHYSVR 330
            :.:.|....|..|.| .|.::||.:||||....:|.|.|     |||.:| |..|.| .|:...:
Human   842 EKSFSGKLRLLVHQR-MHTREKPYECSECGKAFIRNSQL-----IVHQRT-HSGEKPYGCNECGK 899

  Fly   331 TYTQMRRHFLEVH-----GNNPILYACHCCERFFKSGKSL----------SAHLMKKH 373
            |::|  :..|..|     |..|    |.|.|    .||:.          ..|:..||
Human   900 TFSQ--KSILSAHQRTHTGEKP----CKCTE----CGKAFCWKSQLIMHQRTHVDDKH 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	6/16 (38%)
		C2H2 Zn finger	207..225	CDD:275368	7/17 (41%)
		C2H2 Zn finger	237..257	CDD:275368	8/19 (42%)
		C2H2 Zn finger	263..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..311	CDD:275368	7/18 (39%)
		C2H2 Zn finger	352..373	CDD:275368	6/30 (20%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368
		zf-H2C2_2	347..371	CDD:290200
		C2H2 Zn finger	362..382	CDD:275368
		zf-H2C2_2	375..397	CDD:290200
		C2H2 Zn finger	390..410	CDD:275368
		zf-H2C2_2	403..427	CDD:290200
		C2H2 Zn finger	418..438	CDD:275368
		zf-H2C2_2	430..454	CDD:290200
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..494	CDD:275368
		COG5048	497..910	CDD:227381	65/206 (32%)
		C2H2 Zn finger	502..522	CDD:275368
		C2H2 Zn finger	530..550	CDD:275368
		zf-H2C2_2	543..567	CDD:290200
		zf-C2H2	556..578	CDD:278523
		C2H2 Zn finger	558..578	CDD:275368
		C2H2 Zn finger	586..606	CDD:275368
		zf-H2C2_2	599..623	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	626..650	CDD:290200
		C2H2 Zn finger	642..662	CDD:275368
		C2H2 Zn finger	670..690	CDD:275368
		C2H2 Zn finger	698..718	CDD:275368
		zf-H2C2_2	710..734	CDD:290200	2/9 (22%)
		C2H2 Zn finger	726..746	CDD:275368	5/28 (18%)
		zf-H2C2_2	739..763	CDD:290200	7/33 (21%)
		C2H2 Zn finger	754..774	CDD:275368	7/21 (33%)
		C2H2 Zn finger	782..802	CDD:275368	8/21 (38%)
		zf-H2C2_2	794..817	CDD:290200	6/24 (25%)
		C2H2 Zn finger	810..830	CDD:275368	8/19 (42%)
		C2H2 Zn finger	838..858	CDD:275368	6/20 (30%)
		zf-H2C2_2	851..875	CDD:290200	10/24 (42%)
		C2H2 Zn finger	866..886	CDD:275368	11/25 (44%)
		C2H2 Zn finger	894..914	CDD:275368	5/21 (24%)
		zf-H2C2_2	907..929	CDD:290200	9/29 (31%)
		C2H2 Zn finger	922..942	CDD:275368	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910