DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and CTCF

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_006556.1	Gene:	CTCF / 10664	HGNCID:	13723	Length:	727	Species:	Homo sapiens

Alignment Length:	290	Identity:	75/290 - (25%)
Similarity:	126/290 - (43%)	Gaps:	53/290 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LLQGKLECDLHP---EIPACTAPARLMEKLPALGQNFRCGWTDCEREF-VSIVEFQDHIVKHALF 160
            |.||:|.....|   :.|....||:..:|.    :..:..:|:..::. ||:.:|::...:..|.
Human   178 LEQGELPPQEDPSWQKDPDYQPPAKKTKKT----KKSKLRYTEEGKDVDVSVYDFEEEQQEGLLS 238

  Fly   161 EYDIQKTPEDERP-----------KTMCNWAMCHKHMGNKYRLIEHISTHSNKKQVACFHCGELF 214
            |.:.:|...:.:|           |......:|......:..|..|:.:|::::...|..||..|
Human   239 EVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAF 303

  Fly   215 RTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKLLKSHVVRHVNCYKCTMCDMTCSSASSLTTH 279
            ||.|.|.:||      ||::          .|:.            :||..|||...::..|..|
Human   304 RTVTLLRNHL------NTHT----------GTRP------------HKCPDCDMAFVTSGELVRH 340

  Fly   280 IRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKTVHQCEHPDCHYSVRTYTQMRRHFLEVHG 344
            .||:|..:||.|||.||...|..|.|.:|::....:...||..  |.|:.|...:::||.....|
Human   341 RRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSL--CSYASRDTYKLKRHMRTHSG 403

  Fly   345 NNPILYACHCCE-RFFKSGKSLSAHLMKKH 373
            ..|  |.|:.|. ||.:|| ::..|:::||
Human   404 EKP--YECYICHARFTQSG-TMKMHILQKH 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	3/16 (19%)
		C2H2 Zn finger	207..225	CDD:275368	9/17 (53%)
		C2H2 Zn finger	237..257	CDD:275368	1/19 (5%)
		C2H2 Zn finger	263..284	CDD:275368	8/20 (40%)
		C2H2 Zn finger	292..311	CDD:275368	8/18 (44%)
		C2H2 Zn finger	352..373	CDD:275368	7/21 (33%)
CTCF	NP_006556.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..211		8/34 (24%)
		zf-H2C2_5	266..289	CDD:404746	3/22 (14%)
		C2H2 Zn finger	268..288	CDD:275368	3/19 (16%)
		zf-H2C2_2	280..305	CDD:404364	7/24 (29%)
		C2H2 Zn finger	296..316	CDD:275368	11/25 (44%)
		zf-H2C2_2	309..333	CDD:404364	11/51 (22%)
		C2H2 Zn finger	324..347	CDD:275368	9/22 (41%)
		zf-H2C2_5	351..375	CDD:404746	9/23 (39%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		COG5048	<366..500	CDD:227381	21/70 (30%)
		C2H2 Zn finger	381..401	CDD:275368	6/21 (29%)
		C2H2 Zn finger	409..426	CDD:275368	6/17 (35%)
		C2H2 Zn finger	439..457	CDD:275368
		C2H2 Zn finger	469..489	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:404364
		C2H2 Zn finger	525..546	CDD:275368
		C2H2 Zn finger	557..573	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..677
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910