DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17829 and Hinfp

DIOPT Version :9

Sequence 1:	NP_652054.1	Gene:	CG17829 / 47718	FlyBaseID:	FBgn0025635	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_011240678.1	Gene:	Hinfp / 102423	MGIID:	2429620	Length:	519	Species:	Mus musculus

Alignment Length:	486	Identity:	163/486 - (33%)
Similarity:	239/486 - (49%)	Gaps:	64/486 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPAPQPPGKRKKPAELELTCGWRDCQEICTGEWSLNGHIGDHLE---HYAKAQDDRGAHAEHTEH 69
            |.|..||||..:...|.|.|.|..|..:|:.......|:..||:   |.:|.:::.....|  |.
Mouse     5 VKAMSPPGKVPRKENLGLQCEWGSCSFVCSAMEEFFDHVTQHLQQHMHGSKEEEEEDPLEE--EF 67

  Fly    70 QCTWNSCDF-RTENQVEFERHSYYHGYYLNLLLQG----KLECDLHPEIPACTAPARLMEKLPAL 129
            .|.|..|.| ..::..:..||.|:|.|:..|...|    :.:.||.|    |....:....:|..
Mouse    68 SCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQADLSP----CILDFQSRNVIPDT 128

  Fly   130 GQNFRCGWTDCERE---------FVSIVEFQDHIVKHAL-FEYDIQKTPEDERPKTMCNWAMCHK 184
            ..:|.|.|..||..         |.:...|..|:..|:| .||  |...:|.. ...|.|..|..
Mouse   129 PDHFLCLWEHCESSPQVAPAQSVFDNPEWFYRHVDAHSLCCEY--QAVSKDNH-VVQCGWKGCTC 190

  Fly   185 HMGNKYRLIEHISTHSNKKQVACFHCGELFRTKTTLFDHLRRQPENNTNSFQCAQCFKFFATKKL 249
            ...::.:|.||:.:|:.:|.|||..||.:|...|...||:|||...:...|||:.|.|.|||::|
Mouse   191 TFKDRCKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQTSLDQQRFQCSHCSKRFATERL 255

  Fly   250 LKSHVVRHVNCYKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHS 314
            |:.|:..|||.|||.:|||||...|||..|:|:||.:|:|.||..||..|....||.||:. .||
Mouse   256 LRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEDRPYKCDCCDYSCKNLIDLRKHLD-THS 319

  Fly   315 K-TVHQCEHPDCHYSVRTYTQMRRHFLEVH-GNNPILYACHCCERFFKSGKSLSAHLMKKHGFRL 377
            | :.::|:..:|::|.|:.:.::.|..:|| |::...|.||.|::.|..|.:|:.||.|||.|:.
Mouse   320 KESAYRCDFENCNFSARSLSSVKSHHRKVHEGDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKW 384

  Fly   378 PSGHKRFTYRVDENGFYRLETTRLESLEVTQQILSPQVNDSLAKPGTGSCYEIVDPTNTEFERII 442
            ||||.||.|:..|:|:.||:..|.||:|:|||:|                           :::.
Mouse   385 PSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLL---------------------------QQLQ 422

  Fly   443 VSNDP----NEAQLMG---EVVISLPSLAEE 466
            ..:||    ||:.|.|   |.|:..|...||
Mouse   423 EGSDPGLALNESSLQGIVLETVLGGPGPEEE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17829	NP_652054.1	C2H2 Zn finger	182..199	CDD:275368	4/16 (25%)
		C2H2 Zn finger	207..225	CDD:275368	7/17 (41%)
		C2H2 Zn finger	237..257	CDD:275368	9/19 (47%)
		C2H2 Zn finger	263..284	CDD:275368	11/20 (55%)
		C2H2 Zn finger	292..311	CDD:275368	8/18 (44%)
		C2H2 Zn finger	352..373	CDD:275368	9/20 (45%)
Hinfp	XP_011240678.1	C2H2 Zn finger	186..205	CDD:275368	4/18 (22%)
		C2H2 Zn finger	213..235	CDD:275368	10/21 (48%)
		COG5048	<240..393	CDD:227381	70/153 (46%)
		C2H2 Zn finger	243..263	CDD:275368	9/19 (47%)
		C2H2 Zn finger	269..290	CDD:275368	11/20 (55%)
		C2H2 Zn finger	298..318	CDD:275368	8/20 (40%)
		C2H2 Zn finger	326..349	CDD:275368	5/22 (23%)
		C2H2 Zn finger	359..377	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6483
eggNOG	1	0.900	-	-		E1_KOG3608
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9174
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2847
Isobase	1	0.950	-	0	Normalized mean entropy	S3785
OMA	1	1.010	-	-		QHG48157
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005624
OrthoInspector	1	1.000	-	-		oto93125
orthoMCL	1	0.900	-	-		OOG6_107351
Panther	1	1.100	-	-	O	PTHR24391
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5014
SonicParanoid	1	1.000	-	-		X96
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.850