Protein Alignment NF2 and nf2

DIOPT Version :9

• Sequence 1: NP_000259.1
• Gene: NF2 / 4771
• HGNCID: 7773
• Length: 595
• Species: Homo sapiens
• Sequence 2: XP_012820654.1
• Gene: nf2 / 779815
• XenbaseID: XB-GENE-984959
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 602
• Identity: 528/602 - (87%)
• Similarity: 562/602 - (93%)
• Gaps: 15/602 - (2%)

Human     1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQ 65
            |||||||||:|:||||||||||.|||:||||||||||||||||||||||||||||||||||||||
 Frog     1 MAGAIASRMNFTSLKRKQPKTFIVRIITMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQ 65

Human    66 YTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEK 130
            ||:|||:||||||||||||||.|||||||||||||||||.||||||:|||||||||||||||:||
 Frog    66 YTVKDTIAWLKMDKKVLDHDVPKEEPVTFHFLAKFYPENVEEELVQDITQHLFFLQVKKQILEEK 130

Human   131 IYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEH 195
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
 Frog   131 IYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAEEELLPKRVINLYQMTPEMWEERITAWYAEH 195

Human   196 RGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNE 260
            |||.||||||||||||||.||||||||.||||||||||||||||||||||.|||||||.||||||
 Frog   196 RGRTRDEAEMEYLKIAQDTEMYGVNYFLIRNKKGTELLLGVDALGLHIYDLENRLTPKTSFPWNE 260

Human   261 IRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQA 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   261 IRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQA 325

Human   326 REEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQI 390
            |||||||||||||||||||:||||||.||||||||||:||||.|||:||||||||||||||||||
 Frog   326 REEKARKQMERQRLAREKQLREEAERARDELERRLLQLKEEAQMANDALMRSEETADLLAEKAQI 390

Human   391 TEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLK 455
            ||||||||||||||||||||||||||||.|||||||||||:|.|:||:|||||||||.|||:|||
 Frog   391 TEEEAKLLAQKAAEAEQEMQRIKATAIRNEEEKRLMEQKVMETEMLAIKMAEESERRVKEAEQLK 455

Human   456 QDLQEAREAERRAKQKLLEIATKPTY-------PPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTD 513
            |||||||::|||||||||||::|.:|       ...:.:|   |.|:|||:::.|||.:||||||
 Frog   456 QDLQEARDSERRAKQKLLEISSKTSYMQAAGAASSSSTVP---PTDVPSFSMLSDSLPYDFKDTD 517

Human   514 MKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIK 578
            |||||||||||||||||||:||||||||||||||:|||||||:|:||:| ||:    .||.||||
 Frog   518 MKRLSMEIEKEKVEYMEKSRHLQEQLNELKTEIESLKLKERESAMDIMH-ENA----GSKQNTIK 577

Human   579 KLTLQSAKSRVAFFEEL 595
            ||||||.:.||||||||
 Frog   578 KLTLQSTQCRVAFFEEL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NF2	NP_000259.1	B41	23..222	CDD:214604	187/198 (94%)
		FERM_C_ERM	216..312	CDD:270015	92/95 (97%)
		PLN03086	307..>367	CDD:178635	56/59 (95%)
		ERM	347..595	CDD:366293	197/254 (78%)
nf2	XP_012820654.1	B41	24..222	CDD:214604	187/197 (95%)
		FERM_C_ERM	216..312	CDD:270015	92/95 (97%)
		PLN03086	307..>369	CDD:178635	58/61 (95%)
		ERM	347..594	CDD:366293	197/254 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I7791
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2180
Inparanoid	1	1.050	929	1.000	Inparanoid score	I3503
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133350at32523
OrthoFinder	1	1.000	-	-		FOG0006349
OrthoInspector	1	1.000	-	-		oto147764
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4654
SonicParanoid	1	1.000	-	-		X4049
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090