DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NF2 and nf2a

DIOPT Version :9

Sequence 1:	NP_000259.1	Gene:	NF2 / 4771	HGNCID:	7773	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_001122179.1	Gene:	nf2a / 561184	ZFINID:	ZDB-GENE-080722-7	Length:	593	Species:	Danio rerio

Alignment Length:	596	Identity:	493/596 - (82%)
Similarity:	546/596 - (91%)	Gaps:	4/596 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQ 65
            ||.|:||:|.. ||:|||.|.|.|.:|||||::||:||:||:|||||:||||||||||||||||:
Zfish     1 MASALASKMGL-SLRRKQAKIFNVTVVTMDADLEFSCELKWRGKDLFELVCRTLGLRETWFFGLR 64

Human    66 YTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEK 130
            |.:||||||||||||||||||.||||:.|:|||||||||.||||||:||||||||||||.||:|:
Zfish    65 YDVKDTVAWLKMDKKVLDHDVPKEEPIVFYFLAKFYPENVEEELVQDITQHLFFLQVKKSILEEE 129

Human   131 IYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEH 195
            ||||||||||||||||.||||||:|:|||.|||:|:||||||||||||||.||||||||..||||
Zfish   130 IYCPPEASVLLASYAVHAKYGDYNPNVHKPGFLSQDELLPKRVINLYQMTAEMWEERITVCYAEH 194

Human   196 RGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNE 260
            |||.|||||||||||||||||||||||:|||||||.||||||||||||||.:|||||||||||||
Zfish   195 RGRTRDEAEMEYLKIAQDLEMYGVNYFSIRNKKGTSLLLGVDALGLHIYDLDNRLTPKISFPWNE 259

Human   261 IRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQA 325
            |||||||||||.|||:||:.|||||||||||||||||||||||||||||||:.|||||||||.||
Zfish   260 IRNISYSDKEFAIKPVDKRADVFKFNSSKLRVNKLILQLCIGNHDLFMRRRRVDSLEVQQMKTQA 324

Human   326 REEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQI 390
            ||||||||||||||.||||:||:|||.||||:|||:|:::||.:|||||:|||||||||||||||
Zfish   325 REEKARKQMERQRLEREKQLREDAERARDELQRRLIQLQDEAHLANEALLRSEETADLLAEKAQI 389

Human   391 TEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLK 455
            .||||||||||||||||||||||.||||:||||||||||:||||::|||||||||||||||||||
Zfish   390 AEEEAKLLAQKAAEAEQEMQRIKVTAIRSEEEKRLMEQKMLEAEMIALKMAEESERRAKEADQLK 454

Human   456 QDLQEAREAERRAKQKLLEIATKPTYPPMNPIPA-PLPPDIPSFNLIGDSLSFDFKDTDMKRLSM 519
            ||||||||:|||||.|||||.:|..|.|: |:.| .||.|.|:||...::|||||||||||||||
Zfish   455 QDLQEARESERRAKNKLLEITSKTEYSPV-PLSANSLPADGPNFNFSMENLSFDFKDTDMKRLSM 518

Human   520 EIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQS 584
            ||||||||||||||||||||||||||||:||||||||.||||||||::: |:||.:..|||||||
Zfish   519 EIEKEKVEYMEKSKHLQEQLNELKTEIESLKLKERETPLDILHNENTEK-GTSKQSNFKKLTLQS 582

Human   585 AKSRVAFFEEL 595
            .|||||||:||
Zfish   583 TKSRVAFFQEL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NF2	NP_000259.1	B41	23..222	CDD:214604	167/198 (84%)
		FERM_C_ERM	216..312	CDD:270015	87/95 (92%)
		PLN03086	307..>367	CDD:178635	47/59 (80%)
		ERM	347..595	CDD:366293	198/248 (80%)
nf2a	NP_001122179.1	B41	23..221	CDD:214604	167/197 (85%)
		FERM_N	25..85	CDD:286467	49/59 (83%)
		FERM_M	106..221	CDD:278785	100/114 (88%)
		FERM_C_ERM	215..311	CDD:270015	87/95 (92%)
		SKIP_SNW	<323..354	CDD:280827	26/30 (87%)
		GBP_C	<334..462	CDD:303769	109/127 (86%)
		ERM	346..593	CDD:279153	198/248 (80%)
		coiled coil	453..462	CDD:293879	8/8 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194340236
Domainoid	1	1.000	374	1.000	Domainoid score	I5269
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2180
Inparanoid	1	1.050	974	1.000	Inparanoid score	I2434
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50050
OrthoDB	1	1.010	-	-		D189960at7742
OrthoFinder	1	1.000	-	-		FOG0006349
OrthoInspector	1	1.000	-	-		oto49694
orthoMCL	1	0.900	-	-		OOG6_105659
Panther	1	1.100	-	-	LDO	PTHR23281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4654
SonicParanoid	1	1.000	-	-		X4049
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300