Protein Alignment NF2 and Mer

DIOPT Version :9

• Sequence 1: NP_000259.1
• Gene: NF2 / 4771
• HGNCID: 7773
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_001285458.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 630
• Identity: 294/630 - (46%)
• Similarity: 409/630 - (64%)
• Gaps: 52/630 - (8%)

Human    17 KQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKK 80
            |:.::.:||:.|.|:|:||..|.:..|:|||||||||:||||:|:|||||. .:..|:||||:|:
  Fly     7 KKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKR 71

Human    81 VLDHDV---SKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLA 142
            |.|..|   :......|.|.|||:|||..|||:|||||||||||||:.||...|||.||||||||
  Fly    72 VRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLA 136

Human   143 SYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207
            ||||..:||.||...:|.|.||..|||||.|.:.||||||||||||..||.:|....|||.||||
  Fly   137 SYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEY 201

Human   208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFT 272
            |||||||:|||||||.|.||..|:|.|||.::||:|||..::||||.:|.|||||::|:.||:||
  Fly   202 LKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFT 266

Human   273 IKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQ 337
            |:.:|.|:..|.|.|..|.:||:||.||.|||||:|||||.|::|:|||||||:|||.|:|:||:
  Fly   267 IRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERK 331

Human   338 RLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 402
            :..|||::||:||..|.|||:.:..::.|..|||:||.|||||.:|..||:::.||:.:|...||
  Fly   332 KFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKA 396

Human   403 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERR 467
            ...:.||.|::...::.|.||..:|:|:.:|:....::..|:::|..|.::|:::|..|:.|||.
  Fly   397 NHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAERE 461

Human   468 AKQKLLEIATK-------------------PTYPPMNPIPAP------------------LPPDI 495
            |..:|||....                   .|...|..|..|                  |....
  Fly   462 ATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHS 526

Human   496 PSFNLIGDS---LSFDFK-------DTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
            ..:.:.||:   :|.||:       |.:|::::.|:|:..::|:..||.:|.||..|::||...|
  Fly   527 SHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHK 591

Human   551 LKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL 595
            ::|.::.|||| :|...:.|.:|::|:|||...|.|:||||||||
  Fly   592 IEENQSNLDIL-SEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NF2	NP_000259.1	B41	23..222	CDD:214604	126/202 (62%)
		FERM_C_ERM	216..312	CDD:270015	56/95 (59%)
		PLN03086	307..>367	CDD:178635	32/59 (54%)
		ERM	347..595	CDD:366293	92/294 (31%)
Mer	NP_001285458.1	B41	14..216	CDD:214604	126/201 (63%)
		FERM_C_ERM	210..306	CDD:270015	56/95 (59%)
		ERM	341..635	CDD:395622	92/294 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158869
Domainoid	1	1.000	166	1.000	Domainoid score	I3909
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2180
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1169
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50050
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	1	1.000	-	-		FOG0006349
OrthoInspector	1	1.000	-	-		oto88360
orthoMCL	1	0.900	-	-		OOG6_105659
Panther	1	1.100	-	-	O	PTHR23281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4654
SonicParanoid	1	1.000	-	-		X4049
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800