DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NF2 and mto1

DIOPT Version :9

Sequence 1:	NP_000259.1	Gene:	NF2 / 4771	HGNCID:	7773	Length:	595	Species:	Homo sapiens
Sequence 2:	NP_588284.1	Gene:	mto1 / 2539467	PomBaseID:	SPCC417.07c	Length:	1115	Species:	Schizosaccharomyces pombe

Alignment Length:	576	Identity:	113/576 - (19%)
Similarity:	225/576 - (39%)	Gaps:	168/576 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   122 VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQE-ELLPKRVINLYQMTPEMWE 185
            ::|::...|:.|                |..|| .::|  |..|| :.:.|:.|:|..:|.|:
pombe   261 LRKEVFGLKLKC----------------YFLYD-QLNK--FHDQEVQDIMKQNIDLKTLTMEL-- 304

Human   186 ERITAWYAEH----RGRARDE-----------------AEMEYLKIAQDLEMYGVNYFAIRNKKG 229
            :|..|.|.:.    ..|.:.:                 .:..|.:...:||.....:.|:|.:|.
pombe   305 QRAVAGYEKKISGLESRIKPDQSFNLSTPSPAPSNLITLQSRYSQALSELETTKRAFAALRKEKS 369

Human   230 TELLLGVDALGLHIYDPENRLTPKISFPWNEIRNI-------SYSDKEFTIKPLD-------KKI 280
            .:....|.|                   :||.||:       ...:||..::.|:       ||:
pombe   370 KKTNYSVGA-------------------YNEDRNVLSNMLDNERREKEALLQELESLRVQLSKKV 415

Human   281 DVFKFNSSK------LRVNKLI-LQLCIGNHDLFMRRRKADSLEVQ-----------QMKAQARE 327
            .:...|:.:      .|.|:|: :.:.:.|..|.:|:::.|.|..|           :|.|....
pombe   416 PMPAKNTDERVIETLQRSNELLRMDISMQNEALLLRKQENDRLVKQVEELTVALNSGKMNAIVEA 480

Human   328 EKARKQM-ERQRLAREKQMREEAERTR---------DELERRLLQMKEE--------ATMANEAL 374
            |.::.:: :...::|.|...:..|.||         ::.|.:|::|:::        .....|..
pombe   481 ESSKNELWDSMMVSRMKTQEQSIELTRLYKQLQDIEEDYENKLMRMEQQWREDVDQLQEYVEEIT 545

Human   375 MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALK 439
            ...::|.::|::.::.:::..:::.:...|||:|:::.:.|....||...|.::   |.|.|..:
pombe   546 QELQDTKEVLSKSSKESDDYEEVVGKLRTEAEREIEKFEKTIRENEESISLFKE---EVEKLTDE 607

Human   440 MAEESER---RAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLI 501
            :.:.|||   :..|.|:|::.||...|...:||    |.:|..|                 .||:
pombe   608 ITQLSERYNDKCHEFDELQKRLQTLEEENNKAK----EDSTSKT-----------------SNLL 651

Human   502 GDSLSFDFKDTDMKRLSMEIEKE---------------KVEYMEKSKHLQEQLNELKTEIEAL-- 549
             :.|.....:.|..|...|..|:               |:...|:.:.|.:||::||||:|::
pombe   652 -EQLKMTEAEVDSLRKENEENKQVIALKESELVKSNDNKLLLNEQIESLNDQLSQLKTEMESVTT 715

Human   550 ----------KLKERET-ALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEE 594
                      .||||.. .||.|:.:..:..|....|:..|..::...::.....|
pombe   716 SKESLADYLSNLKERHNDELDSLNKKLREFEGILSSNSSLKSEIEERNNQYVTLRE 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NF2	NP_000259.1	B41	23..222	CDD:214604	22/121 (18%)
		FERM_C_ERM	216..312	CDD:270015	21/116 (18%)
		PLN03086	307..>367	CDD:178635	15/88 (17%)
		ERM	347..595	CDD:366293	62/296 (21%)
mto1	NP_588284.1	Cnn_1N	252..319	CDD:285263	18/78 (23%)
		Fib_alpha	511..611	CDD:285864	17/102 (17%)
		Mto2_bdg	1052..1101	CDD:289572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000