Protein Alignment ATP1A2 and ENA5

DIOPT Version :10

• Sequence 1: NP_000693.1
• Gene: ATP1A2 / 477
• HGNCID: 800
• Length: 1020
• Species: Homo sapiens
• Sequence 2: NP_010323.3
• Gene: ENA5 / 851608
• SGDID: S000002445
• Length: 1091
• Species: Saccharomyces cerevisiae
• Alignment Length: 1134
• Identity: 320/1134 - (28%)
• Similarity: 488/1134 - (43%)
• Gaps: 267/1134 - (23%)

Human    42 HKLSLDELGRKYQVDLSKGLTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGA 106
            |.|:.:|........|::|||...:...|...|.|.|..............|:.....::|.|..
Yeast    18 HTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVISM 82

Human   107 ILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIR 171
            .:.|       |:.|      ...|.|::.|:.|.......||.|::|.|:|.||:....|.|||
Yeast    83 AISF-------AVRD------WITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIR 134

Human   172 EGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLE 236
            .|:...||:::||.||:..||.||.:|||||:|.:.....|.|.|||||.|.::..........|
Yeast   135 NGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEE 199

Human   237 TR-----NICFFSTNCVEGTARGIVIATGDRTVMGRIATLA---SGLEVGRTPIAMEIEH---FI 290
            |.     |:.|.|:..|:|.|:||||.|...:.:|:||...   ||| :.|.|....:::   ..
Yeast   200 TSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGL-ISRDPSKSWLQNTWIST 263

Human   291 QLITGVAVFLGVS--------FFVLSLILGYSWLEAVIFLIGIIVAN------------------ 329
            :.:||  .|||.:        ...|:::|  .|: ||:|.| |::|:
Yeast   264 KKVTG--AFLGTNVGTPLHRKLSKLAVLL--FWI-AVLFAI-IVMASQKFDVDKRVAIYAICVAL 322

Human   330 --VPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-- 390
              :|..|:..:|:.:::.|..|..:|.:|:.|:::|.||:.:.|||||||||||.:|....:|
Yeast   323 SMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIP 387

Human   391 ---------------------------------------------FDNQIHEADTTEDQSGATFD 410
                                                         |.::::|.|..||.....|.
Yeast   388 RFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQ 452

Human   411 KRSPTWTALSRIAGLCNRAVFK----------AGQENISVSKRDTAGDASESALLKCIELSCGSV 465
            |    |...:.:|.:.  .|||          .....|::....|..|...:||..  |.|....
Yeast   453 K----WLETATLANIA--TVFKDDATDCWKAHGDPTEIAIQVFATKMDLPHNALTG--EKSTNQS 509

Human   466 RK-----MRDRNPK--------VAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCST 517
            .:     :...|.|        :||.||:||.|...|::....: :::.:..|||.|.|:..||:
Yeast   510 NENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVYYNNHN-ETYNIYGKGAFESIISCCSS 573

Human   518 ILVQGKE----IPL-DKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPT 577
              ..||:    .|| |.:::...:|.| .|...|.|||||...:           |..|::|...
Yeast   574 --WYGKDGVKITPLTDCDVETIRKNVY-SLSNEGLRVLGFASKS-----------FTKDQVNDDQ 624

Human   578 EK------------LCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI 630
            .|            |.|:||:.:.||||.....||.|...|||.|.|:|||...||||||:.|||
Yeast   625 LKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGI 689

Human   631 ISE-----GNETVEDIAARLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFART 690
            :..     ..|.|:.:                   |:.||....::.|::|::  ....:|.||.
Yeast   690 LPTNLYHYSQEIVDSM-------------------VMTGSQFDGLSEEEVDDL--PVLPLVIARC 733

Human   691 SPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASI 755
            |||.|:.::|...|:....|:|||||||||:||.|::||||||:||||||:|:|::|.|||||||
Yeast   734 SPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASI 798

Human   756 VTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANI---------PLPLGTVTILCIDLGT 811
            :..|||||.:.||::|.:...|..|:.:    .|::|..:         ..||..|.:|.|.:.|
Yeast   799 LNAVEEGRRMTDNIQKFVLQLLAENVAQ----ALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVT 859

Human   812 DMVPAISLAYEAAESDIMKRQPRNSQTDKLVNERLI-SMAYGQIGMIQALGGFFTYFVILAENGF 875
            ...||:.|..|.|..|:|.|.|.:|:......|.:| :.|||.|.....:..|
Yeast   860 SCFPAMGLGLEKAAPDLMDRPPNDSEVGIFTWEVIIDTFAYGIIMTGSCMASF------------ 912

Human   876 LPSRLLGIRLDWDDRTMNDLEDSYGQEW--TYEQRKVVEFTCHTAFFASIVVVQWADLI----IC 934
             ...|.||.   ..|..:|.:.:|....  .|..|        :|.||::.   |..||    :.
Yeast   913 -TGSLYGIN---SGRLGHDCDGTYNSSCRDVYRSR--------SAAFATMT---WCALILAWEVV 962

Human   935 KTRRN-------------SVFQQGMKNKIL----IFGLLEETALAAF-LSYCPGMGVALRMY-PL 980
            ..||:             ..|:....|:.|    |||.     ::|| :.|.|.:...:.:: |:
Yeast   963 DMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGF-----VSAFPVVYIPVINDKVFLHKPI 1022

Human   981 KVTWWFCAFPYSLLIFIYDEVRKLILRRY 1009
            ...|.. |..:::..:|..|:.|...|||
Yeast  1023 GAEWGL-AIAFTIAFWIGAELYKCGKRRY 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	320/1134 (28%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..231		8/18 (44%)
ENA5	NP_010323.3	ATPase-IID_K-Na	11..1055	CDD:130586	320/1134 (28%)