DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP1A2 and Atpalpha

DIOPT Version :9

Sequence 1:	NP_000693.1	Gene:	ATP1A2 / 477	HGNCID:	800	Length:	1020	Species:	Homo sapiens
Sequence 2:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster

Alignment Length:	1021	Identity:	769/1021 - (75%)
Similarity:	879/1021 - (86%)	Gaps:	13/1021 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     2 GRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRA 66
            |:...|...||          |..|::.||:||:|:.:|.||:|.:||.:::|.....||::.:|
  Fly    32 GQYKSRRKMPA----------KVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKA 86

Human    67 QDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLG 131
            ::.|.||||||||||..||||||||:.|||||::||||||||||:||.|||:..:||::||||||
  Fly    87 KENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLG 151

Human   132 VVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDR 196
            :||:|||||||.||||||:||||||:||||||||.|.|||||||:.:.||::|:||:||||.|||
  Fly   152 IVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDR 216

Human   197 VPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGD 261
            :|||:|||.:...||||||||||||||:|..||||||||||:|:.|||||.|||||:|:||:.||
  Fly   217 IPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGD 281

Human   262 RTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGII 326
            .|||||||.|||||:.|.||||.||.|||.|||||||||||:|||::.||||.||:|||||||||
  Fly   282 HTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGII 346

Human   327 VANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWF 391
            ||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
  Fly   347 VANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWF 411

Human   392 DNQIHEADTTEDQSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLK 456
            ||||.||||||||||..:|:.||.:.||||||.|||||.||.||:.:.:.|::.:|||||:||||
  Fly   412 DNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLK 476

Human   457 CIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDS--PQSHVLVMKGAPERILDRCSTIL 519
            |:||:.|.|..:|.||.|:||:|||||||||:||||.||:  |: ::|||||||||||:|||||.
  Fly   477 CMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPR-YLLVMKGAPERILERCSTIF 540

Human   520 VQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVG 584
            :.|||..||:||::||.|||||||||||||||||...|||.|:|.||||:||::|||.:.|.|||
  Fly   541 INGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVG 605

Human   585 LMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPM 649
            ||||||||||||||||.|||||||||||||||||||||||||.|||||||||||||||.|||||:
  Fly   606 LMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPV 670

Human   650 SQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGD 714
            |:||||||||.||||::|:|::|:||||||:.|||||||||||||||||||||||.|||||||||
  Fly   671 SEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGD 735

Human   715 GVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS 779
            ||||||||||||||:||||:|||||||||||||||||||||||||||||||||||||||||||||
  Fly   736 GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS 800

Human   780 NIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNE 844
            |||||:|||.||:.:||||||||||||||||||||||||||||.||:|||||.||:...|||||.
  Fly   801 NIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNS 865

Human   845 RLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRK 909
            |||||||||||||||..|||.||||:|||||||.:|.|||..||.:.:|||.|||||||||..||
  Fly   866 RLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRK 930

Human   910 VVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVA 974
            .:|:|||||||.|||||||||||||||||||:|||||:|..|.|||:.||.|||||||||||...
  Fly   931 TLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKG 995

Human   975 LRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY 1020
            |||||||:.|||.|.|::|.||||||.|:..|||.||||:|:||||
  Fly   996 LRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		6/28 (21%)
		ATPase-IIC_X-K	30..1020	CDD:273445	761/991 (77%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231		15/18 (83%)
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	762/996 (77%)
		Cation_ATPase_N	58..132	CDD:214842	44/73 (60%)
		E1-E2_ATPase	152..383	CDD:278548	181/230 (79%)
		Cation_ATPase	445..539	CDD:289987	60/94 (64%)
		COG4087	<695..770	CDD:226572	69/74 (93%)
		Cation_ATPase_C	817..1025	CDD:279079	160/207 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I438
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1568	1.000	Inparanoid score	I89
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm41159
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	LDO	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840