DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gpo1 and gpd2

DIOPT Version :9

Sequence 1:	NP_001097332.1	Gene:	Gpo1 / 47611	FlyBaseID:	FBgn0022160	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_005165898.1	Gene:	gpd2 / 751628	ZFINID:	ZDB-GENE-030131-4869	Length:	729	Species:	Danio rerio

Alignment Length:	731	Identity:	441/731 - (60%)
Similarity:	557/731 - (76%)	Gaps:	29/731 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GVTAASACVGSVLASYTLDRWNTPHVVNNATVPPKR------KRTLPPRADQIKSLMSGEEFDVL 67
            |..|.:..||  |:.:...|.|.|.....|.|..:.      |..||.|.:|:.:|.:.||||||
Zfish    13 GGGAVATAVG--LSQFFEYRKNQPKRARLAYVEAQGELKVPFKDALPTREEQLSTLRNTEEFDVL 75

  Fly    68 IIGGGATGAGCALDSVTRGLKTALVELDDFASGTSSRSTKLIHGGVRYLQKAILGLDLEQYRMVK 132
            ::||||||:|||||:|||.|||||||..||:||||||||||||||||||||||:.||.|||.|||
Zfish    76 VVGGGATGSGCALDAVTRNLKTALVERSDFSSGTSSRSTKLIHGGVRYLQKAIMKLDYEQYMMVK 140

  Fly   133 EALAERATMLESAPHLTHPLPIMLPVYTWWQVPYYWVGIKAYDLVAGDRNVKSSYYLSKKDALEL 197
            |||.|||.:||.||||:.|||||||||.|||:||||.|||.||||||.:.:||||.|||..|||.
Zfish   141 EALHERANLLEIAPHLSAPLPIMLPVYKWWQLPYYWAGIKMYDLVAGSQCLKSSYVLSKSKALEF 205

  Fly   198 FPMLKKDKLCGAIVYYDGQQDDARMCLAVALTAARHGATVCNHVEVKELLKK-DDGTGKQVLCGA 261
            |||||||||.|||||||||.:||||.||:|||||||||.:.|:.||..|||| |..||::.:|||
Zfish   206 FPMLKKDKLVGAIVYYDGQHNDARMNLAIALTAARHGAAIANYTEVVHLLKKPDPKTGQEKVCGA 270

  Fly   262 KVKDHISGKEFTVKAKCIVNAAGPFTDSIRKMDNPTVKSICCPSSGVHIVLPGYYSPDQMGLLDP 326
            :.:|.::|:||.::|||::||.||||||:|||||....:||.||:|||||:|||||||.||||||
Zfish   271 RCRDVVTGQEFDIRAKCVINATGPFTDSLRKMDNQKTANICQPSAGVHIVIPGYYSPDNMGLLDP 335

  Fly   327 STSDGRVIFFLPWQRQTIAGTTDLPCEITHNPTPTEDEIQFILNEIKNYLNADVEVRRGDVLSAW 391
            :||||||||||||::.|||||||.|.|:|.:|.|.||:|.|||:|::|||:.||||||||||:||
Zfish   336 ATSDGRVIFFLPWEKMTIAGTTDTPTEVTAHPIPMEDDINFILSEVRNYLSPDVEVRRGDVLAAW 400

  Fly   392 SGIRPLVSDPNKDDTQSLARNHIVHVSPSNLITIAGGKWTTYRAMAEHTIDAAIKACNLK--PER 454
            |||||||:||:..||||:.|||||:||.|.|||||||||||||:|||.|:||||||.||.  |.|
Zfish   401 SGIRPLVTDPSSKDTQSICRNHIVNVSDSGLITIAGGKWTTYRSMAEETLDAAIKAHNLSAGPSR 465

  Fly   455 AEAVTSYLKIEGGQGWTPTMYIRLVQDFGLECEVAQHLAKSYGDRAFAVSKMASLTGKRWPIIGN 519
            ...:|    :|||:.||||:|||||||:|||.|||||||.:||.|:|.|:|||.:|||||||:|.
Zfish   466 TVGLT----LEGGKDWTPTLYIRLVQDYGLENEVAQHLAATYGGRSFEVAKMAQVTGKRWPIVGK 526

  Fly   520 RIHPEFPYIDAEIRYGVREYACTAVDMIARRLRLAFLNVQAAQEALPVIVDIMGEELGWSKDEKE 584
            |:..|||||::|::|.::||||||:|:|:||.||.|||||||.||||.||:|||:||.|::.:|:
Zfish   527 RLVSEFPYIESEVQYAIKEYACTAIDVISRRTRLGFLNVQAADEALPRIVEIMGKELQWTEQKKK 591

  Fly   585 RQIKHATEFLANEMGH-----SVNRTSKERIPIKLSKEEIQTYIKRFQLIDKDKKGYVSINDIRR 644
            .:::.|..||..|||:     .:::|::    |.|:.:|:..|.|||...||:.||:::..|:::
Zfish   592 EELEAAKNFLYLEMGYKARSEQLSKTTE----ISLTPQEVARYKKRFYKFDKESKGFITTVDVQQ 652

  Fly   645 ALKSFGDGDVSGEQLHEILREIDTNMNGQVELDEYLQMMSAIKTGDVAYSRFARMAELEEQKHEA 709
            .|:.... .:....|||||.|:|.|.||||||||:||:|||::.|.::.||.|.:.:..|   |.
Zfish   653 VLERLSI-HIDENALHEILNEVDLNKNGQVELDEFLQLMSAVQRGQISDSRLAILLKTAE---EG 713

  Fly   710 ANLK-QISVDRSGGGL 724
            .:|: .:||||||||:
Zfish   714 LDLRGPVSVDRSGGGV 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpo1	NP_001097332.1	PLN02464	9..594	CDD:215257	386/593 (65%)
		DAO_C	458..583	CDD:293506	80/124 (65%)
		EFh	624..684	CDD:238008	27/59 (46%)
		EF-hand_7	624..683	CDD:290234	27/58 (47%)
gpd2	XP_005165898.1	PLN02464	2..601	CDD:215257	386/593 (65%)
		NADB_Rossmann	71..>109	CDD:304358	29/37 (78%)
		DAO_C	464..590	CDD:293506	81/129 (63%)
		EFh	629..691	CDD:238008	28/62 (45%)
		EF-hand_7	631..690	CDD:290234	27/59 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575711
Domainoid	1	1.000	567	1.000	Domainoid score	I224
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H352
Inparanoid	1	1.050	868	1.000	Inparanoid score	I401
OMA	1	1.010	-	-		QHG53921
OrthoDB	1	1.010	-	-		D232701at33208
OrthoFinder	1	1.000	-	-		FOG0002536
OrthoInspector	1	1.000	-	-		oto40636
orthoMCL	1	0.900	-	-		OOG6_101157
Panther	1	1.100	-	-	LDO	PTHR11985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R509
SonicParanoid	1	1.000	-	-		X1659
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940