DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gpo1 and Gpo2

DIOPT Version :9

Sequence 1:	NP_001097332.1	Gene:	Gpo1 / 47611	FlyBaseID:	FBgn0022160	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_610295.1	Gene:	Gpo2 / 35689	FlyBaseID:	FBgn0033190	Length:	713	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	317/694 - (45%)
Similarity:	487/694 - (70%)	Gaps:	15/694 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NATVPPKRKRTLPPRADQIKSLMSGEEFDVLIIGGGATGAGCALDSVTRGLKTALVELDDFASGT 101
            ::|..|:.||.||.|...::: .....:|:|||||||.|:|||||:.||||||||||.:||.|||
  Fly    29 DSTPVPQMKRELPTRKMCLEA-FKRTHYDILIIGGGAVGSGCALDAATRGLKTALVEANDFGSGT 92

  Fly   102 SSRSTKLIHGGVRYLQKAILGLDLEQYRMVKEALAERATMLESAPHLTHPLPIMLPVYTWWQVPY 166
            ||:|:||:|||:|.|::||..||:..:|.|:.:|.||:.:.:.||||:.|:||:|||:.|||.|.
  Fly    93 SSKSSKLLHGGLRDLEQAISRLDVAAFRRVRCSLQERSHIGKLAPHLSQPVPILLPVHHWWQAPL 157

  Fly   167 YWVGIKAYDLVAGDRNVKSSYYLSKKDALELFPMLKKDKLCGAIVYYDGQQDDARMCLAVALTAA 231
            |::.:|.|.|:| .:..:|..|||..||||:||||::.:|.||.|:|:||.|||||||:||||||
  Fly   158 YYMKLKIYHLMA-PKATRSFQYLSADDALEVFPMLRRQELFGAFVFYEGQHDDARMCLSVALTAA 221

  Fly   232 RHGATVCNHVEVKELLKKDDGTGKQVLCGAKVKDHISGKEFTVKAKCIVNAAGPFTDSIRKMDNP 296
            |:||.:|||::|..|:|..||.    :.||:..|.::||:::::||.:|||.|..:||:|:|::.
  Fly   222 RYGADICNHMKVSRLIKNKDGN----VAGAEAVDQLTGKKYSIRAKVVVNATGHMSDSLRQMEDS 282

  Fly   297 TVKSICCPSSGVHIVLPGYYSPDQMGLLDPSTSDGRVIFFLPWQRQTIAGTTDLPCEITHNPT-P 360
            ..|.:|..|....||:|.:|.|:::|:.||.|..||.|||||||..|:.|::|.|..:....| |
  Fly   283 EAKPLCTRSWSSIIVMPRFYCPEEVGVFDPHTPSGRSIFFLPWQGHTLVGSSDEPLNLPEQDTQP 347

  Fly   361 TEDEIQFILNEIKNYLNADVEVRRGDVLSAWSGIRPLVSDPNKDDT--QSLARNHIVHVSPSNLI 423
            ||.::|.:|:.:|:::..:.:|||.|||:.|.|.:||   |.:.||  .:..:||::.:.|.|::
  Fly   348 TETDVQSLLDCVKHFVTPNFDVRRCDVLAVWGGYKPL---PVQSDTLHHTRFKNHVIQLGPRNML 409

  Fly   424 TIAGGKWTTYRAMAEHTIDAAIKACNLKPERAEAVTS-YLKIEGGQGWTPTMYIRLVQDFGLECE 487
            :|.||.|:::|.:||.|::|||:..:|.|.|.|:||: ..|::|..||:|.|:||||||||:|.:
  Fly   410 SIVGGTWSSFRVLAEKTVNAAIRYGDLSPLRKESVTAESCKLDGASGWSPKMFIRLVQDFGMERD 474

  Fly   488 VAQHLAKSYGDRAFAVSKMASLTGKRWPIIGNRIHPEFPYIDAEIRYGVREYACTAVDMIARRLR 552
            ||:||:.:||..||.|:..|..:||.|||:|.|:|.|||||:||::.|||::|||..||:|||||
  Fly   475 VAEHLSNTYGSNAFKVAVSADSSGKAWPIVGKRLHSEFPYIEAEVKQGVRDFACTLEDMVARRLR 539

  Fly   553 LAFLNVQAAQEALPVIVDIMGEELGWSKDEKERQIKHATEFLANEMGHSVNRT-SKERIPIKLSK 616
            :||||||.|:|.||.:.:||.:||.||:|:.::||:....||.::||.....: |:..||||:|.
  Fly   540 VAFLNVQVAEEILPQVANIMAKELNWSRDQIKKQIRQTRTFLNSQMGQLTKESASQMSIPIKMSV 604

  Fly   617 EEIQTYIKRFQLIDKDKKGYVSINDIRRALKSFGDGDVSGEQLHEILREIDTNMNGQVELDEYLQ 681
            .:::.:..:|:.:|.:..|||||.|..:|:|:.|..:|..:.:|::||:||.:..|:|.|.|:|.
  Fly   605 RQVRKFAGQFRQMDDNNTGYVSIADCCKAMKTMGVKEVPVDLMHDVLRDIDVHAQGKVNLYEFLL 669

  Fly   682 MMSAIKTGDVAYSRFARMAELEEQKHEAANLKQI-SVDRSGGGL 724
            :||||..|:..|.|:||:....:::.:.:|...: .::|:||||
  Fly   670 LMSAIVQGNTEYLRYARLYLDHKRQMQGSNFPTVMQMERAGGGL 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpo1	NP_001097332.1	PLN02464	9..594	CDD:215257	270/560 (48%)
		DAO_C	458..583	CDD:293506	72/125 (58%)
		EFh	624..684	CDD:238008	22/59 (37%)
		EF-hand_7	624..683	CDD:290234	22/58 (38%)
Gpo2	NP_610295.1	PLN02464	8..583	CDD:215257	272/562 (48%)
		NADB_Rossmann	55..>85	CDD:304358	23/29 (79%)
		DAO_C	443..569	CDD:293506	71/125 (57%)
		EFh	614..672	CDD:298682	22/57 (39%)
		EF-hand_7	614..671	CDD:290234	22/56 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440839
Domainoid	1	1.000	77	1.000	Domainoid score	I3086
eggNOG	1	0.900	-	-		E1_COG0578
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	526	1.000	Inparanoid score	I286
Isobase	1	0.950	-	0	Normalized mean entropy	S668
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232701at33208
OrthoFinder	1	1.000	-	-		FOG0002536
OrthoInspector	1	1.000	-	-		otm51316
orthoMCL	1	0.900	-	-		OOG6_101157
Panther	1	1.100	-	-	P	PTHR11985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1659
	12	11.750