DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gpo1 and gpdh-3

DIOPT Version :9

Sequence 1:	NP_001097332.1	Gene:	Gpo1 / 47611	FlyBaseID:	FBgn0022160	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_492115.1	Gene:	gpdh-3 / 172509	WormBaseID:	WBGene00012031	Length:	722	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	412/736 - (55%)
Similarity:	521/736 - (70%)	Gaps:	33/736 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RMFKFGVTAASACVGSVLA----------SYTLDRWNTPHVVNNATVPPKRKRTLPPRADQIKSL 58
            |..|.||...:....:|||          ....|.:.|.|....|.:..:....||.|.|.:.:|
Worm     5 RFTKTGVAVVATSAAAVLALDMTNERRFQRQVKDHFRTVHADRLAELNKRAPSALPTRKDILTNL 69

  Fly    59 MSGEEFDVLIIGGGATGAGCALDSVTRGLKTALVELDDFASGTSSRSTKLIHGGVRYLQKAILGL 123
            ..|||||||||||||||||.|||:.||||||||||||||:|||||||||||||||||||.||:.|
Worm    70 SKGEEFDVLIIGGGATGAGVALDAQTRGLKTALVELDDFSSGTSSRSTKLIHGGVRYLQAAIMKL 134

  Fly   124 DLEQYRMVKEALAERATMLESAPHLTHPLPIMLPVYTWWQVPYYWVGIKAYDLVAGDRNVKSSYY 188
            ||||||||||||.||..:||.||||:.|||||||:|..|||||||.||||||.|:|.|.:|:|::
Worm   135 DLEQYRMVKEALFERHNLLEIAPHLSSPLPIMLPIYKLWQVPYYWSGIKAYDFVSGKRVLKNSFF 199

  Fly   189 LSKKDALELFPMLKKDKLCGAIVYYDGQQDDARMCLAVALTAARHGATVCNHVEVKELLKKDDGT 253
            ::|..|||.||||:.:.|.||::|||||.:||||.||:.|||.||||...|||.|::|.|  |.|
Worm   200 INKSQALERFPMLRNESLKGALIYYDGQHNDARMNLAIILTAIRHGAACANHVRVEKLNK--DET 262

  Fly   254 GKQVLCGAKVKDHISGKEFTVKAKCIVNAAGPFTDSIRKMDNP-TVKSICCPSSGVHIVLPGYYS 317
            ||.:  ||.|:|.::|.|:.:|||.::||.||||||||.|.:| |.:.||.|||||||.||||||
Worm   263 GKVI--GAHVRDMVTGGEWDIKAKAVINATGPFTDSIRLMGDPETARPICAPSSGVHITLPGYYS 325

  Fly   318 PDQMGLLDPSTSDGRVIFFLPWQRQTIAGTTDLPCEITHNPTPTEDEIQFILNEIKNYLNADVEV 382
            |...|||||.||||||||||||:|.|||||||.|.::|.:|.||:.:|:|||.||:.||:.||.|
Worm   326 PSNTGLLDPDTSDGRVIFFLPWERMTIAGTTDAPSDVTLSPQPTDHDIEFILQEIRGYLSKDVSV 390

  Fly   383 RRGDVLSAWSGIRPLVSDPNKDDTQSLARNHIVHVSPSNLITIAGGKWTTYRAMAEHTIDAAIKA 447
            |||||:|||||:||||.||||.||:|||||||:.|..|.|||||||||||||.|||.|:|..::.
Worm   391 RRGDVMSAWSGLRPLVRDPNKKDTKSLARNHIIEVGKSGLITIAGGKWTTYRHMAEETVDRVVEV 455

  Fly   448 CNLKPERAEAVTSYLKIEGGQGWTPTMYIRLVQDFGLECEVAQHLAKSYGDRAFAVSKMASLTGK 512
            ..||.|.. .||..|.:||...|....||.||||:|:|.:|||||:.:||||||.|::|..:|||
Worm   456 HGLKTENG-CVTPGLLLEGAHDWNSLQYIHLVQDYGMEVDVAQHLSNTYGDRAFVVARMCKMTGK 519

  Fly   513 RWPIIGNRIHPEFPYIDAEIRYGVREYACTAVDMIARRLRLAFLNVQAAQEALPVIVDIMGEELG 577
            ||||:|.|:||||||:|||:||.||||||||:|:||||:||||||..||.|.||.:|.:||:|||
Worm   520 RWPIVGQRLHPEFPYLDAEVRYAVREYACTAIDVIARRMRLAFLNTYAAHEVLPDVVRVMGQELG 584

  Fly   578 WSKDEKERQIKHATEFLANEMGHSVNRTSKERIPIKLSKEEIQTYIKRFQLIDKDKKGYVSINDI 642
            ||..|:..|::.|..|:..|||.:..:|:...:.:.|:|||:|...:|||.:|||:||::::||:
Worm   585 WSSAEQRAQLEKARTFIDMEMGQNAKQTAVSNVALNLTKEEMQRAKERFQQLDKDRKGHITVNDL 649

  Fly   643 RRALKSFGDGDVSGEQLHEILREIDTNMNGQVELDEYLQMMSAIKTGDVAYSRFARMAELEEQKH 707
            |:..:.... .:....|||:|.|:|.|.||::|:.|:.|:.|.:|.|.:..:|.
Worm   650 RKHFREHNQ-KIDERVLHELLNEVDLNKNGEIEIAEFFQLYSGLKGGQLTGNRL----------- 702

  Fly   708 EAANLKQI----SVDRSGGGL 724
             ...|.:|    ||:|:.||:
Worm   703 -VGYLDEIHGTPSVNRACGGI 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpo1	NP_001097332.1	PLN02464	9..594	CDD:215257	366/595 (62%)
		DAO_C	458..583	CDD:293506	79/124 (64%)
		EFh	624..684	CDD:238008	23/59 (39%)
		EF-hand_7	624..683	CDD:290234	23/58 (40%)
gpdh-3	NP_492115.1	PLN02464	46..602	CDD:215257	359/560 (64%)
		DAO_C	464..590	CDD:293506	79/125 (63%)
		EFh	628..685	CDD:238008	21/57 (37%)
		EF-hand_7	629..689	CDD:290234	23/60 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157378
Domainoid	1	1.000	521	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E1_COG0578
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H352
Inparanoid	1	1.050	813	1.000	Inparanoid score	I243
Isobase	1	0.950	-	0	Normalized mean entropy	S668
OMA	1	1.010	-	-		QHG53921
OrthoDB	1	1.010	-	-		D232701at33208
OrthoFinder	1	1.000	-	-		FOG0002536
OrthoInspector	1	1.000	-	-		oto19062
orthoMCL	1	0.900	-	-		OOG6_101157
Panther	1	1.100	-	-	LDO	PTHR11985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R509
SonicParanoid	1	1.000	-	-		X1659
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790