DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP1A1 and Atpalpha

DIOPT Version :9

Sequence 1:NP_000692.2 Gene:ATP1A1 / 476 HGNCID:799 Length:1023 Species:Homo sapiens
Sequence 2:NP_732572.1 Gene:Atpalpha / 48971 FlyBaseID:FBgn0002921 Length:1041 Species:Drosophila melanogaster


Alignment Length:1032 Identity:771/1032 - (74%)
Similarity:888/1032 - (86%) Gaps:14/1032 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     6 GR-DKYEPAAVSEQGD-------------KKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYG 56
            || |.|..|.|....|             |...|..|..::|:||:|:.:|.||:|.:||::::.
  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQ 74

Human    57 TDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAAT 121
            |....||:.|:|.|.|.||||||||||..||||:|||:.|||||:|||||||||||:||||||:|
  Fly    75 THPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAST 139

Human   122 EEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVV 186
            .|||.:||||||:|||||||:||.||||||:|||||||||||||||.|.|||.|||:::.||::|
  Fly   140 SEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204

Human   187 VGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVE 251
            :||:||||.|||||||:|||.|...||||||||||||||:|..:||:||||||:|:||||||.||
  Fly   205 LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE 269

Human   252 GTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYT 316
            |||:|:|:..||.|||||||.|||||:.|:||||.||.||||:||||||||||:||:::.||.|.
  Fly   270 GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYH 334

Human   317 WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 381
            ||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
  Fly   335 WLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 399

Human   382 TQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRA 446
            ||||||||||||||||.||||||:||||.:|:||..:.||||||.|||||.|:..|:.:||||:.
  Fly   400 TQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKE 464

Human   447 VAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAP 511
            |:|||||:|||||:||..|.|..:|:|..||.|:|||||||||:|||:..:|::|::||||||||
  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAP 529

Human   512 ERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDV 576
            ||||:|||:|.::|||:.||||:|:||.|||:|||||||||||||...||.:::|.||:|:|||:
  Fly   530 ERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI 594

Human   577 NFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETV 641
            |||||||.||||:||||||||||||||.|||||||||||||||||||||||||.|||||||||||
  Fly   595 NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV 659

Human   642 EDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQ 706
            ||||.|||||||:||||:|||.||||::|:|::|:|||:||:|||||||||||||||||||||||
  Fly   660 EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQ 724

Human   707 RQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 771
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   725 RMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 789

Human   772 LKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQP 836
            ||||||||||||||||:|||.||:.:||||||||||||||||||||||||||||.||:|||||.|
  Fly   790 LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP 854

Human   837 RNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDS 901
            |:|..|||||.|||||||||||||||..|||.||||:|||||||..|.|:|..||.:.:||:.||
  Fly   855 RDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDS 919

Human   902 YGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAA 966
            |||:|||..||.:|:|||||||:||||||||||:||||||||:|||||:|..|.|||..||.|||
  Fly   920 YGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAA 984

Human   967 FLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY 1023
            ||||||||...|||||||..|||.|.|::|.||:|||.|:..:||.||||:|:||||
  Fly   985 FLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP1A1NP_000692.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 13/46 (28%)
ATPase-IIC_X-K 30..1023 CDD:273445 759/992 (77%)
Phosphoinositide-3 kinase binding. /evidence=ECO:0000250 82..84 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..235 13/18 (72%)
AtpalphaNP_732572.1 ATPase-IIC_X-K 45..1041 CDD:273445 760/995 (76%)
Cation_ATPase_N 58..132 CDD:214842 46/73 (63%)
E1-E2_ATPase 152..383 CDD:278548 179/230 (78%)
Cation_ATPase 445..539 CDD:289987 60/93 (65%)
COG4087 <695..770 CDD:226572 71/74 (96%)
Cation_ATPase_C 817..1025 CDD:279079 156/207 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 476 1.000 Domainoid score I438
eggNOG 1 0.900 - - E2759_KOG0203
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1568 1.000 Inparanoid score I89
Isobase 1 0.950 - 0 Normalized mean entropy S851
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D50082at33208
OrthoFinder 1 1.000 - - FOG0000283
OrthoInspector 1 1.000 - - otm41159
orthoMCL 1 0.900 - - OOG6_100215
Panther 1 1.100 - - O PTHR43294
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3604
SonicParanoid 1 1.000 - - X416
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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