DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and RPS6KA4

DIOPT Version :10

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_003933.1 Gene:RPS6KA4 / 8986 HGNCID:10433 Length:772 Species:Homo sapiens


Alignment Length:359 Identity:140/359 - (38%)
Similarity:216/359 - (60%) Gaps:26/359 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   606 GTQRQYSLNDFELIRVIGRGSYAKVLMVEL---RRTRRIYAMKVIKK-ALVTDDEDIDWVQTEKH 666
            |.:.:.|:.:|||::|:|.|:|.||.:|..   ....::|||||::| |||...:..:..:||:.
Human    23 GHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87

  Fly   667 VFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFL 731
            |.|.....||||.||..|||.::|..::::|.||::..|:.:::...|...|.|..||.|||..|
Human    88 VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHL 152

  Fly   732 HEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGI-RPGDTTSTFCGTPNYIAPEILRGE-DYGF 794
            |:.|||||||||:|||||.||||.|||:|:.||.: ...:.|.:||||..|:||||:|.: .:|.
Human   153 HKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGK 217

  Fly   795 SVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFL 859
            :||||:||:||:|:|.|.|||.|.|     ::||:..:.:.||:.:...|..:...|..:|:..|
Human   218 AVDWWSLGILLFELLTGASPFTLEG-----ERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLL 277

  Fly   860 NKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTG-EAV 923
            .|:|..|||...:.| .::.:||||:.:||..|..:::..||:|::.|:.|:.||..|||. |.|
Human   278 CKDPKKRLGAGPQGA-QEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPV 341

  Fly   924 -----QLTPDDDHVIDNIDQSEFEGFEYVNPLLM 952
                 ...|.|..:        |:|:.:|.|.::
Human   342 YSPPGSPPPGDPRI--------FQGYSFVAPSIL 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_aPKC 496..550 CDD:410344
STKc_aPKC 620..947 CDD:270740 133/338 (39%)
RPS6KA4NP_003933.1 STKc_MSK2_N 32..364 CDD:270765 137/345 (40%)
Protein Kinases, catalytic domain 404..714 CDD:473864
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Required for nuclear targeting and association with MAPK14 725..772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..772
Blue background indicates that the domain is not in the aligned region.

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