Protein Alignment aPKC and SCH9

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_012075.1
• Gene: SCH9 / 856612
• SGDID: S000001248
• Length: 824
• Species: Saccharomyces cerevisiae
• Alignment Length: 961
• Identity: 236/961 - (24%)
• Similarity: 390/961 - (40%)
• Gaps: 262/961 - (27%)

  Fly    28 VNIVQQEEEEEQPCLPQQQQHQQTQQQQQSQTCPSTPSANQQGSGNLCYSPTCRSRCSSPCPGSP 92
            :|....:...:......|.||...|....:.   |:.:.|..|.       .|:...|.||..|.
Yeast     2 MNFFTSKSSNQDTGFSSQHQHPNGQNNGNNN---SSTAGNDNGY-------PCKLVSSGPCASSN 56

  Fly    93 CGSI-------TPPPPPMLTSSQQHLHSNKNCPAAQQLMTHLDYAARRQSLDQLDSPQSKYFDIQ 150
            .|::       |..|   .|:..|.|::........:           .:|.|:.|
Yeast    57 NGALFTNFTLQTATP---TTAISQDLYAMGTTGITSE-----------NALFQMKS--------- 98

  Fly   151 ANQLSDIMCRGAVVSSIQSANN---TLTRGVSMHSRSGSAHGSHHGS--HHSHSHHGSAHGSLGC 210
                   |..|  :||:.:.|:   |:.......:.:|:.||...|:  .:|...:.|:..:..|
Yeast    99 -------MNNG--ISSVNNNNSNTPTIITTSQEETNAGNVHGDTGGNSLQNSEDDNFSSSSTTKC 154

  Fly   211 LQGGVGVGVGTGSTGSIGMMSAGHIDTG-DYDVPHPHPYTHHYMQTTASVTPPHTSLSRPGSAGA 274
            |       :.:.|:.||....|.....| |.|:|...      ::.|........:.|:......
Yeast   155 L-------LSSTSSLSINQREAAAAAYGPDTDIPRGK------LEVTIIEARDLVTRSKDSQPYV 206

  Fly   275 VCQGHDSGSDSSQGCGGSIMGGMLVMGHPGHMGSL-GHHSAGSGSLGRCSSRCHNTNTTTTDDSG 338
            ||.     .:||:          .:...|..:|:: .:::..:.:....:...:|.|..|..|:.
Yeast   207 VCT-----FESSE----------FISNGPESLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAA 256

  Fly   339 ----GGSSGGGGVPGTMSSASMAVGMPGMLMDYH------HSHHSGSAGSGLNGCGGGSIAGGSI 393
                ..:||..|..           :|.  :..|      ::|.|.|....||.|  .|:...|.
Yeast   257 SQHHNNNSGWNGSQ-----------LPS--IKEHLKKKPLYTHRSSSQLDQLNSC--SSVTDPSK 306

  Fly   394 GGRSSVLGTIHNG--HGHHHQQYHHECIHYERLPIPVPIPTVPMGVAPSSQQMSQHQLQSEEEIE 456
            ...:|..|: .||  :...|..:||                          :.:...|.|..|:
Yeast   307 RSSNSSSGS-SNGPKNDSSHPIWHH--------------------------KTTFDVLGSHSEL- 343

  Fly   457 PAYATVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGL 521
                                 |.|:|.          ..:.|:|                    |
Yeast   344 ---------------------DISVYD----------AAHDHMF--------------------L 357

  Fly   522 GRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACE 586
            |:     ::...::|...|  ..:|.....:|.|.:                  |.:||......
Yeast   358 GQ-----VRLYPMIHNLAH--ASQHQWHSLKPRVID------------------EVVSGDILIKW 397

  Fly   587 THDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKAL 651
            |:...               .:|.|...|||::|::|:|::.:|..|:.:.|:|||||||:.|.:
Yeast   398 TYKQT---------------KKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKV 447

  Fly   652 VTDDEDIDWVQTEKHVFET--ASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPE 714
            :....:|.....|:::..|  :.:.||:|||...||||:.|:.|.:::.||:|.:|:|::.|..|
Yeast   448 IVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSE 512

  Fly   715 EHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTP 779
            :.|:||.||:.|||..||:..|:|||||.:|:|||..|:|.|.|:|:.|..::  |.|:|||||.
Yeast   513 DRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLK--DRTNTFCGTT 575

  Fly   780 NYIAPEILRGE-DYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRI 843
            .|:|||:|..| .|...||:|:||||::||..|.|||    .:||..:     ::|.|....::.
Yeast   576 EYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPF----FAENNQK-----MYQKIAFGKVKF 631

  Fly   844 PRS-LSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDS 907
            ||. ||....|.:||.||:||..|||...:.  .::.:||||.::|||.|::|::.|||||.|.|
Yeast   632 PRDVLSQEGRSFVKGLLNRNPKHRLGAIDDG--RELRAHPFFADIDWEALKQKKIPPPFKPHLVS 694

  Fly   908 DRDLANFPPEFTGEA----------VQLTPDDDHVIDNIDQSEFEGFEYVN 948
            :.|.:||.||||..:          :..||     :....|::|.||.:|:
Yeast   695 ETDTSNFDPEFTTASTSYMNKHQPMMTATP-----LSPAMQAKFAGFTFVD 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	7/53 (13%)
		STKc_aPKC	620..947	CDD:270740	135/340 (40%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	53/380 (14%)
		STKc_Sck1_like	418..738	CDD:270738	134/337 (40%)