Protein Alignment aPKC and TPK2

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_015121.1
• Gene: TPK2 / 855898
• SGDID: S000006124
• Length: 380
• Species: Saccharomyces cerevisiae
• Alignment Length: 347
• Identity: 120/347 - (34%)
• Similarity: 191/347 - (55%)
• Gaps: 19/347 - (5%)

  Fly   574 PYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRT 638
            |:..:....:..:...|..::....|:..|.  ::.:|:|:||:::|.:|.||:.:|.:|.....
Yeast    30 PHHDLQQRQQQQQQRQHQQLLTSQLPQKSLV--SKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHN 92

  Fly   639 RRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLM 703
            .|.||:||:||..|...:.::....|:.:.:.. .||||:.:...||....:|.|::::.||:|.
Yeast    93 GRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLV-EHPFLIRMWGTFQDARNIFMVMDYIEGGELF 156

  Fly   704 YHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRP 768
            ..:::.:|.|...|:|||||:.|||.:||...|||||||.:|:|||..||||:||:|..||   .
Yeast   157 SLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKE---V 218

  Fly   769 GDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLF 833
            ...|.|.||||:|||||::..:.|..|||||:||||:||||||.:||         ...|....:
Yeast   219 QTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPF---------YDTTPMKTY 274

  Fly   834 QVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVT 898
            :.||:..:..|.........:|...:..:...|:| :.:|...||.:||:|..:.||.|..|.:.
Yeast   275 EKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIG-NLQSGSRDIKAHPWFSEVVWERLLAKDIE 338

  Fly   899 PPFKPRLDS---DRDLANFPPE 917
            .|::|.:.|   |..|.:..||
Yeast   339 TPYEPPITSGIGDTSLFDQYPE 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344
		STKc_aPKC	620..947	CDD:270740	112/301 (37%)
TPK2	NP_015121.1	STKc_PKA_like	69..358	CDD:270732	112/302 (37%)