Protein Alignment aPKC and TPK3

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_012755.1
• Gene: TPK3 / 853688
• SGDID: S000001649
• Length: 398
• Species: Saccharomyces cerevisiae
• Alignment Length: 418
• Identity: 130/418 - (31%)
• Similarity: 208/418 - (49%)
• Gaps: 64/418 - (15%)

  Fly   535 VHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPP 599
            ||::|..........:....:||  |.|:....|..|.|.|...||
Yeast    38 VHEECSSNTPVEINGRNSGKLKE--EASAGICLVKKPMLQYRDTSG------------------- 81

  Fly   600 EDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTE 664
                      :|||:||:::|.:|.||:.:|.::......|.||:|.:||..:...:.::....|
Yeast    82 ----------KYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDE 136

  Fly   665 KHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALN 729
            :.:....| |||::.:...||...::|.|::::.||:|...:::.:|.|...|:|||||:.|||.
Yeast   137 RRMLSIVS-HPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 200

  Fly   730 FLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGF 794
            :||.|.|||||||.:|:|||..||||:||:|..|   ...|.|.|.||||:|||||::..:.|..
Yeast   201 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDVTYTLCGTPDYIAPEVVSTKPYNK 262

  Fly   795 SVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFL 859
            |||||:.|||:||||||.:||        .:.||.. .::.||...::.|......|..:||..:
Yeast   263 SVDWWSFGVLIYEMLAGYTPF--------YNSNTMK-TYENILNAELKFPPFFHPDAQDLLKKLI 318

  Fly   860 NKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQ 924
            .::.::||| :.::...|:.:||:|..:.||.|..:.:..|::|                  .:|
Yeast   319 TRDLSERLG-NLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEP------------------PIQ 364

  Fly   925 LTPDDDHVIDNIDQSEFE-GFEYVNPLL 951
            ....|....|...:.||. |.:..:|.:
Yeast   365 QGQGDTSQFDRYPEEEFNYGIQGEDPYM 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	3/14 (21%)
		STKc_aPKC	620..947	CDD:270740	111/327 (34%)
TPK3	NP_012755.1	STKc_PKA_like	86..376	CDD:270732	110/321 (34%)