Protein Alignment aPKC and PKC1

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 765
• Identity: 193/765 - (25%)
• Similarity: 281/765 - (36%)
• Gaps: 313/765 - (40%)

  Fly   481 IYRRGA--RRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLV 543
            ::|.||  .|..:::..:||.|..|.|.....||||.|   .|...||:|..||.|.||||:..|
Yeast   396 LHRHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGD---FLRYTGFQCQDCKFLCHKKCYTNV 457

  Fly   544 QKHC-------TDQPEPLV---------------------------------------------- 555
            ...|       ||..|..:
Yeast   458 VTKCIAKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSECGIMCHAQ 522

  Fly   556 --------------------------KERAEESSDPIP--------------------------V 568
                                      |...|:....:|                          .
Yeast   523 CAHLVPDFCGMSMEMANKILKTIQDTKRNQEKKKRTVPSAQLGSSIGTANGSDLSPSKLAERANA 587

  Fly   569 PLPPLP------------------------------------------------YEAMSGGAEAC 585
            ||||.|                                                |...:.||:..
Yeast   588 PLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFIDENEAYLNFTEGAQQT 652

  Fly   586 ----------------------------------------------------------------- 585
                                                                             
Yeast   653 AEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESKDDLMRDELELWKAQREEMELEIKQDSGEIQ 717

  Fly   586 --------------------------------ETH----------------DHA----------- 591
                                            .||                |||
Yeast   718 EDLEVDHIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETFQIEQDHASKEVLQETVSL 782

  Fly   592 -----HIVAPPPPEDPLEPGT------------QRQYSLNDFELIRVIGRGSYAKVLMVELRRTR 639
                 |.......:.|.:..|            :|:.||::|.|::|:|:|::.||::.:.:.|.
Yeast   783 APTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTD 847

  Fly   640 RIYAMKVIKKALVTDDEDIDWVQTEKHVF--ETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDL 702
            |:.|:||:||..:..:.||:..:.||.||  .|.:.||||..|:..|||.:|::|.:||:.||||
Yeast   848 RLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDL 912

  Fly   703 MYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIR 767
            |:|:|.| ||....|:|||||:.|||.:.|:.|:|||||||:|:||..|||||:.|||:||:.:.
Yeast   913 MWHVQNQ-RLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMW 976

  Fly   768 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYL 832
            .|:.||||||||.::|||||:.::|..:|||||.|||||:||..:|||         ..:.||.:
Yeast   977 YGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPF---------SGDDEDEV 1032

  Fly   833 FQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQV 897
            |..||......|..::.....:.:|.|.|:|..|||.....| .:::..|||:|::::.:...:|
Yeast  1033 FNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDA-DEVMEEPFFRNINFDDILNLRV 1096

  Fly   898 TPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYV 947
            .||:.|.:.|..|.:.|..|||.....|||... |:....|.||.||.::
Yeast  1097 KPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPS-VLTTSQQEEFRGFSFM 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	24/60 (40%)
		STKc_aPKC	620..947	CDD:270740	139/328 (42%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	23/53 (43%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	0/57 (0%)
		STKc_PKC	828..1145	CDD:270722	139/328 (42%)