DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and Prkch

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_112347.1	Gene:	Prkch / 81749	RGDID:	621888	Length:	683	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	229/535 - (42%)
Similarity:	310/535 - (57%)	Gaps:	77/535 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGL-GRQGFKCIQCKLLVHKKCHKLVQKH 546
            |:.|.| |::::||||.|.|....:..:|::|::.|||: |:||::|..|..:|||:||.|:...
  Rat   158 RQRAMR-RRVHQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTA 221

  Fly   547 CTDQPEPLVKERAEESSDPIPVPLP------------------PLPYEAMSGGAEA--CETHDHA 591
            ||.| ..:.|..|:.:.....:.:|                  .|.:..|..|.:.  |:.:.|.
  Rat   222 CTCQ-NNINKVDAKIAEQRFGINIPHKFNVHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHI 285

  Fly   592 HIVAPPPPE--------------DPLEPGT-------------QRQ------------------Y 611
            ...|...|.              ..|:||.             :||                  :
  Rat   286 RCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLISRSTLRRQGKEGSKEGNGIGVNSSSRF 350

  Fly   612 SLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPF 676
            .:::||.|||:|:||:.||::..::.|..:||:||:||.::..|:|::...|||.:...|.||||
  Rat   351 GIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPF 415

  Fly   677 LVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDL 741
            |..|..|||||.|||||:|||.|||||:|:|:.||..|..||||||||..||.||||||||||||
  Rat   416 LTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDL 480

  Fly   742 KLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLY 806
            ||||||||||||.||.|:|||||||..|.||:||||||:|||||||:...||.:|||||:|||||
  Rat   481 KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLY 545

  Fly   807 EMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHR 871
            |||.|.:||:    :||     ||.||:.||...:..|..|...|..:||.|:.|||..|||...
  Rat   546 EMLCGHAPFE----AEN-----EDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT 601

  Fly   872 ESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNI 936
            :....:|:.|||||.:||..|..:|:.|||:||:.|..|::||.|:|..|...|||.|:..:..|
  Rat   602 QGGEHEILRHPFFKEIDWVQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMI 666

  Fly   937 DQSEFEGFEYVNPLL 951
            :|.||..|.||:|.|
  Rat   667 NQDEFRNFSYVSPEL 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	21/52 (40%)
		S_TKc	616..884	CDD:214567	153/267 (57%)
		STKc_aPKC	620..947	CDD:270740	178/326 (55%)
Prkch	NP_112347.1	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..225	CDD:278556	21/52 (40%)
		C1_1	246..298	CDD:278556	7/51 (14%)
		S_TKc	355..614	CDD:214567	153/267 (57%)
		STKc_nPKC_eta	359..681	CDD:270742	181/330 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920