DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and si:ch211-195b13.1

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001070770.2	Gene:	si:ch211-195b13.1 / 768159	ZFINID:	ZDB-GENE-030131-7626	Length:	423	Species:	Danio rerio

Alignment Length:	416	Identity:	159/416 - (38%)
Similarity:	234/416 - (56%)	Gaps:	44/416 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 VKERAEESSDPIP--VPLPPLPYEAMSGG--------------AEACETHDHAHIVAPPPPEDPL 603
            :|||....:|.|.  |..||:...|..|.              ...|.||          |...|
Zfish    26 IKERKMGLNDFIQRLVSNPPICQHADVGSFLKIDENQNEELDENLLCLTH----------PRSSL 80

  Fly   604 EPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVF 668
            ...||.:.|  ||:.:::||:||:.|||:...:.....||:||::|.::...::...:..|:.|.
Zfish    81 AEETQIKPS--DFDYLKIIGKGSFGKVLLARHKENELYYAVKVLQKKIIMKKKEQKHIMAERSVL 143

  Fly   669 ETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHE 733
            .....||||||||..|||..:|:||:::|.||:|.||:||:|...|..||||||||:.||.:||.
Zfish   144 MKNIKHPFLVGLHYSFQTTDKLYFVLDYVNGGELFYHLQRERVFLEPRARFYAAEIASALGYLHS 208

  Fly   734 KGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDW 798
            ..|:|||||.:|:|||.:|||.|||:|:||||:.|..||:||||||.|:|||:|:.:.|..:|||
Zfish   209 LHIVYRDLKPENILLDSQGHIVLTDFGLCKEGLDPNGTTTTFCGTPEYLAPEVLQKQAYDRTVDW 273

  Fly   799 WALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNP 863
            |.||.:|:|||.|..||        ..:||.: ::..||.|.:.:..::|.....:|:|.|:|:.
Zfish   274 WCLGSVLFEMLYGLPPF--------YSRNTAE-MYNNILHKPLVLKPNVSNAGRDLLEGLLHKDR 329

  Fly   864 ADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLT-- 926
            ..|||  .:..|:::..|.||..::|:.|..|::.|||.|.:....||.:|.||||...|..:
Zfish   330 TKRLG--SKDDFLELKFHSFFSPINWDDLMAKRIVPPFIPTVTGPTDLRHFDPEFTHLPVSTSLC 392

  Fly   927 -PDDDHVIDNIDQS--EFEGFEYVNP 949
             .|:.||..::.::  .|.||.|..|
Zfish   393 NTDNLHVTSSVREAAGAFPGFSYGPP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556
		S_TKc	616..884	CDD:214567	115/267 (43%)
		STKc_aPKC	620..947	CDD:270740	137/331 (41%)
si:ch211-195b13.1	NP_001070770.2	S_TKc	91..348	CDD:214567	115/267 (43%)
si:ch211-195b13.1	NP_001070770.2	STKc_SGK	95..415	CDD:270727	137/330 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910