Protein Alignment aPKC and prkcd

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: XP_002934267.1
• Gene: prkcd / 733756
• XenbaseID: XB-GENE-478663
• Length: 683
• Species: Xenopus tropicalis
• Alignment Length: 623
• Identity: 216/623 - (34%)
• Similarity: 316/623 - (50%)
• Gaps: 119/623 - (19%)

  Fly   429 PIPTVPMGVAPSSQQMSQHQLQSE--EEIEPAYATVFPNV----PQAPGLSCDGEDRSIY----R 483
            |:....:||:..:::..:...:||  .:::| .|.|..:|    ..|...|...||..:.    |
 Frog    80 PLSEATVGVSVLAERCKKGNGKSEFWLDLQP-QAKVLMSVQYFLEDADLKSSVREDEGLVTINRR 143

  Fly   484 RGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCT 548
            |||.:..|::.:..|.|.|..|.:..||:.|:|.:|||.:||:||.||...:||||.:::...||
 Frog   144 RGAIKQAKIHYIKNHEFIATFFGQPTFCSVCRDFVWGLNKQGYKCRQCNAAIHKKCIEMIIGRCT 208

  Fly   549 ------------------DQPE---------------------PLVKE--RAEESSDPIPVPLPP 572
                              |.|.                     .|||:  :.:|.:..:
 Frog   209 GTAANSRDTMFQKERFNIDMPHRFKVYNYKSPTFCDHCGSLLWGLVKQGLKCDECAMNV------ 267

  Fly   573 LPYEAMSGGAEACETH------------------------DHAHI---VAPPPPEDPLEPGTQRQ 610
             .::..:..|..|..:                        |:..|   |.|..|..|:...|..|
 Frog   268 -HHKCQNKVANLCGINQKLLAEALNQVSMKSSSRKSDSGLDNIAIYQGVNPKTPGLPMPDATDNQ 331

  Fly   611 Y-------------------SLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDE 656
            |                   .:::|...:|:|:||:.|||:.||:.....:|:|.:||.:|..|:
 Frog   332 YDRLWEGSSPHPHISLSSRLKIDNFVFHKVLGKGSFGKVLLAELKGKGEYFAIKALKKDVVLIDD 396

  Fly   657 DIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYA 721
            |::....||.|...|..:|||..::..|||...||||:||:.|||||:|:|.:.|.....|.|||
 Frog   397 DVECTMVEKRVLALAWENPFLTHIYCSFQTKEHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYA 461

  Fly   722 AEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEI 786
            :||...|.|||.|||||||||||||:||.:||||:.|:|||||.:...:..|||||||:||||||
 Frog   462 SEIICGLQFLHSKGIIYRDLKLDNVMLDKDGHIKIADFGMCKENVYGDNKASTFCGTPDYIAPEI 526

  Fly   787 LRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRA 851
            |:|..|.||||||:.||||||||.|:|||         ..:.||.||:.|.:.|...||.::..:
 Frog   527 LQGLKYTFSVDWWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRQDTPHYPRWITKES 582

  Fly   852 ASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPP 916
            ..:|:....:.|..|||     ...:|..|||||.::|..|||:::.|||||::.|..|.:||..
 Frog   583 KDILERLFEREPTKRLG-----VVGNIKVHPFFKTINWTALERRELEPPFKPKVKSPSDYSNFDR 642

  Fly   917 EFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSL 954
            ||..|..:|:..|.::||::|||.|.||.::||.:..|
 Frog   643 EFLSEKPRLSFSDKNLIDSMDQSAFHGFSFINPKMERL 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	23/69 (33%)
		S_TKc	616..884	CDD:214567	126/267 (47%)
		STKc_aPKC	620..947	CDD:270740	154/326 (47%)
prkcd	XP_002934267.1	C1_1	158..207	CDD:365894	21/48 (44%)
		C1_1	230..280	CDD:365894	5/56 (9%)
		STKc_nPKC_delta	360..675	CDD:173710	154/328 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920