Protein Alignment aPKC and AURKC

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001015878.1
• Gene: AURKC / 6795
• HGNCID: 11391
• Length: 309
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 91/330 - (27%)
• Similarity: 161/330 - (48%)
• Gaps: 43/330 - (13%)

  Fly   576 EAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRR 640
            :|...|.|....:..|        :.|..| ..|:.:::|||:.|.:|:|.:..|.:..|:.:..
Human    12 KAQPAGEELATANQTA--------QQPSSP-AMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHF 67

  Fly   641 IYAMKVIKKALVTDDEDIDW-----VQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGG 700
            |.|:||:.|:.: :.|.::.     ::.:.|:     .||.::.|::.|....|::.::|:...|
Human    68 IVALKVLFKSQI-EKEGLEHQLRREIEIQAHL-----QHPNILRLYNYFHDARRVYLILEYAPRG 126

  Fly   701 DLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEG 765
            :|...:|:..:|.|:.......|::.||.:.|:|.:|:||:|.:|:||...|.:|:.|:|....
Human   127 ELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVH- 190

  Fly   766 IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTED 830
             .|.....|.|||.:|:.||::.|..|...||.|.:|||.||:|.|..||:.|..||.
Human   191 -TPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSET------- 247

  Fly   831 YLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERK 895
              ::.||:..:|.|.|:.:.|..::...|...|.:||      ....|:.||      |.....:
Human   248 --YRRILKVDVRFPLSMPLGARDLISRLLRYQPLERL------PLAQILKHP------WVQAHSR 298

  Fly   896 QVTPP 900
            :|.||
Human   299 RVLPP 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344
		STKc_aPKC	620..947	CDD:270740	81/286 (28%)
AURKC	NP_001015878.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		5/28 (18%)
		STKc_Aurora-B_like	36..305	CDD:271019	85/297 (29%)
		Interaction with BIRC5. /evidence=ECO:0000269|PubMed:27332895	292..309		4/12 (33%)