DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and RPS6KB2

DIOPT Version :10

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_003943.2 Gene:RPS6KB2 / 6199 HGNCID:10437 Length:482 Species:Homo sapiens


Alignment Length:402 Identity:152/402 - (37%)
Similarity:234/402 - (58%) Gaps:23/402 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   556 KERAEESSDPIPVPLPPLPY-EAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELI 619
            :|.:|...:|...|....|. |..:.|.|....::...:.     |..:..|.:| ...:.|||:
Human    12 EEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELT-----ETSVNVGPER-IGPHCFELL 70

  Fly   620 RVIGRGSYAKVLMV-ELRRTR--RIYAMKVIKKA-LVTDDEDIDWVQTEKHVFETASNHPFLVGL 680
            ||:|:|.|.||..| :::.|.  :||||||::|| :|.:.:|....:.|:::.|:. .|||:|.|
Human    71 RVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV-KHPFIVEL 134

  Fly   681 HSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDN 745
            ...|||..:|:.::|.:.||:|..|::|:....|:.|.||.|||:|||..||.:||||||||.:|
Human   135 AYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPEN 199

  Fly   746 VLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLA 810
            ::|..:|||||||:|:|||.|..|..|.|||||..|:|||||....:..:||||:||.|:|:||.
Human   200 IMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLT 264

  Fly   811 GRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAF 875
            |..||......:..|:         |:...:.:|..|:..|..::|.||.:||:.|:|.....| 
Human   265 GSPPFTAENRKKTMDK---------IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDA- 319

  Fly   876 MDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSE 940
            .|:..||||::|:|:.|...:|.|||:|.|.|:.|::.|...||.:....:|||..:.::.:|: 
Human   320 ADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQA- 383

  Fly   941 FEGFEYVNPLLM 952
            |.||.||.|.::
Human   384 FLGFTYVAPSVL 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_aPKC 496..550 CDD:410344
STKc_aPKC 620..947 CDD:270740 135/330 (41%)
RPS6KB2NP_003943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 3/13 (23%)
STKc_p70S6K 70..392 CDD:270736 137/333 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..482
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12529391 471..477
Blue background indicates that the domain is not in the aligned region.

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