DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and RPS6KA2

DIOPT Version :10

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:XP_006715612.1 Gene:RPS6KA2 / 6196 HGNCID:10431 Length:761 Species:Homo sapiens


Alignment Length:465 Identity:156/465 - (33%)
Similarity:232/465 - (49%) Gaps:83/465 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   503 KRFN-RRAFCAYCQ----------DRIWGLGRQ--GFKCIQCKLLVHKKCHKLVQKHCTDQPEPL 554
            |:|. ||.|..|.:          .|:.||.|:  |.|.:.....:|.:     :.....:.|.:
Human     6 KKFAVRRFFSVYLRRKSRSKSSSLSRLEGLNRRAAGIKVVTIADCLHSR-----EPETQHEEEGV 65

  Fly   555 VKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELI 619
            |||             ..:.:....|..:|                ||           :.|||:
Human    66 VKE-------------IDISHHVKEGFEKA----------------DP-----------SQFELL 90

  Fly   620 RVIGRGSYAKVLMVELRRTR-----RIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVG 679
            :|:|:|||.||.:|  |:.:     ::|||||:|||.:...:.:. .:.|:.:.... ||||:|.
Human    91 KVLGQGSYGKVFLV--RKVKGSDAGQLYAMKVLKKATLKVRDRVR-SKMERDILAEV-NHPFIVK 151

  Fly   680 LHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLD 744
            ||..|||..:|:.:::|:|||||...:.::....||..:||.||::|||:.||..||||||||.:
Human   152 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPE 216

  Fly   745 NVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEML 809
            |:|||.|||||:||:|:.||.|.......:||||..|:|||::....:..|.|||:.|||::|||
Human   217 NILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEML 281

  Fly   810 AGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESA 874
            .|..||......|.         ..:||:..:.:|:.||..|.|:|:....:||.:|||...:..
Human   282 TGSLPFQGKDRKET---------MALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGV 337

  Fly   875 FMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQS 939
             .:|..||||..:||..|.||::.|||||.:....|..:|.||||..    ||.|...:.....:
Human   338 -EEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTAR----TPTDSPGVPPSANA 397

  Fly   940 E--FEGFEYV 947
            .  |.||.:|
Human   398 HHLFRGFSFV 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_aPKC 496..550 CDD:410344 13/59 (22%)
STKc_aPKC 620..947 CDD:270740 131/333 (39%)
RPS6KA2XP_006715612.1 STKc_RSK_N 91..407 CDD:270734 131/333 (39%)
STKc_RSK3_C 439..731 CDD:271080
Blue background indicates that the domain is not in the aligned region.

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