DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and sgk3

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001103937.1	Gene:	sgk3 / 564523	ZFINID:	ZDB-GENE-070424-62	Length:	486	Species:	Danio rerio

Alignment Length:	535	Identity:	176/535 - (32%)
Similarity:	267/535 - (49%)	Gaps:	111/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 PQAPGLS--CDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCI 529
            |..|.:|  |..|.|...:|     ..:|:|...:.:.:.|..|.:..:  |:::...::.|..:
Zfish     5 PSCPNVSIPCYNEQRDKKKR-----YTVYKVMVSVGRHEWFVFRRYAEF--DKLYNTLKKQFPAL 62

  Fly   530 QCKLLVHK----------------KCHKLVQK---HCTDQPEPLVK-----ERAEESSDPIPVPL 570
            ..|:...:                ..|:.:|:   |......|.||     ::|:..||
Zfish    63 NLKIPAKRIFGDNFDPEFIKQRRAGLHEFIQRIVSHSQLCSHPDVKVFLQMDKAKNFSD------ 121

  Fly   571 PPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSL----------NDFELIRVIGRG 625
                      |:|               .||.....|.|..:|          .||:.::|||:|
Zfish   122 ----------GSE---------------DEDDKSNSTSRNINLGPSANPHAKPTDFDFLKVIGKG 161

  Fly   626 SYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRL 690
            |:.|||:.:.:|..:.||:||::|.::.:..:...:..|::|......||||||||..|||..:|
Zfish   162 SFGKVLLAKRKRDGKCYAIKVLQKKVILNRREQKHIMAERNVLLKNVKHPFLVGLHYSFQTTDKL 226

  Fly   691 FFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIK 755
            :||::||.||:|.:|:|::|..||..|:||.||::.||.:||...|:|||||.:|:|||.:|||.
Zfish   227 YFVLDFVNGGELFFHLQKERTFPEPRAKFYIAEMASALGYLHSLNIVYRDLKPENILLDSQGHIV 291

  Fly   756 LTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGA 820
            |||:|:|||||...|||:||||||.|:|||:||.:.|..:||||.||.:|||||.|..||.....
Zfish   292 LTDFGLCKEGISQADTTTTFCGTPEYLAPEVLRKQPYDNTVDWWCLGSVLYEMLYGLPPFYSRDT 356

  Fly   821 SENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFK 885
            .|         ::..||.|.:.:....|..|.|:|:..|.|:...||| :|:. |.::..|.||.
Zfish   357 HE---------MYDNILHKELVMRPGASTAAWSILQTLLEKDHTRRLG-YRDD-FNEVKEHEFFS 410

  Fly   886 NMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQ----------------LTPDDDHVID 934
            :::|..||:|::.|||.|.::|..|::||.||||.|.|.                :..||
Zfish   411 SINWYDLEQKKLPPPFNPSVESQYDISNFDPEFTEETVPNSVCFSSGPSIVNASVMEADD----- 470

  Fly   935 NIDQSEFEGFEYVNP 949
                 .|.||.|..|
Zfish   471 -----AFLGFSYAPP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	8/70 (11%)
		S_TKc	616..884	CDD:214567	118/267 (44%)
		STKc_aPKC	620..947	CDD:270740	142/342 (42%)
sgk3	NP_001103937.1	PX_CISK	6..114	CDD:132780	19/114 (17%)
		S_TKc	152..409	CDD:214567	118/267 (44%)
		STKc_SGK3	155..480	CDD:270755	143/345 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910