Protein Alignment aPKC and PRKCI

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_002731.4
• Gene: PRKCI / 5584
• HGNCID: 9404
• Length: 596
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 376/626 - (60%)
• Similarity: 438/626 - (69%)
• Gaps: 96/626 - (15%)

  Fly   387 SIAGGSIGGRSSVLGTIHNGHGHHHQ----QYHHECI---HYERLPIPVPIPTVPM-GVAPSSQQ 443
            ::|||..|             .|.||    .|:...|   |:|        |::.. |:....:.
Human    13 TVAGGGSG-------------DHSHQVRVKAYYRGDIMITHFE--------PSISFEGLCNEVRD 56

  Fly   444 M---SQHQL---------------QSEEEIEPAYAT------------VFPNVPQAPGLSCDGED 478
            |   ...||               .|:.|:|.|:..            |||.||:.||:.|.|||
Human    57 MCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGED 121

  Fly   479 RSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLV 543
            :||||||||||||||..|||.||||||||||.||.|.||||||||||:|||.|||||||||||||
Human   122 KSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLV 186

  Fly   544 QKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAP--PPPEDPLEPG 606
            ...|.....|      :|       |:.|:...:|..        |||..|.|  |...:.|:..
Human   187 TIECGRHSLP------QE-------PVMPMDQSSMHS--------DHAQTVIPYNPSSHESLDQV 230

  Fly   607 TQRQYSLN--------------DFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDED 657
            .:.:.::|              ||:|:||||||||||||:|.|::|.|||||||:||.||.||||
Human   231 GEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDED 295

  Fly   658 IDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAA 722
            ||||||||||||.||||||||||||||||.||||||||:|.|||||:||||||:|||||||||:|
Human   296 IDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 360

  Fly   723 EISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEIL 787
            |||||||:|||:|||||||||||||||.|||||||||||||||:|||||||||||||||||||||
Human   361 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 425

  Fly   788 RGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAA 852
            |||||||||||||||||::||:|||||||:.|:|:|||||||||||||||||.|||||||||:||
Human   426 RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490

  Fly   853 SVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPE 917
            ||||.||||:|.:|||||.::.|.||..||||:|:||:::|:|||.|||||.:..:..|.||..:
Human   491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQ 555

  Fly   918 FTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 958
            ||.|.||||||||.::..|||||||||||:||||||.|:||
Human   556 FTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	43/53 (81%)
		STKc_aPKC	620..947	CDD:270740	262/326 (80%)
PRKCI	NP_002731.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/22 (18%)
		Regulatory domain	2..253		101/281 (36%)
		Required for interaction with RAB2	2..28		7/27 (26%)
		PB1_aPKC	26..108	CDD:99725	15/89 (17%)
		Interaction with PARD6A	72..91		4/18 (22%)
		Pseudosubstrate. /evidence=ECO:0000250	125..134		8/8 (100%)
		C1_aPKC	139..193	CDD:410344	43/53 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		3/25 (12%)
		STKc_aPKC_iota	233..596	CDD:270769	274/362 (76%)