DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment aPKC and PRKCH

DIOPT Version :10

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:XP_047287541.1 Gene:PRKCH / 5583 HGNCID:9403 Length:782 Species:Homo sapiens


Alignment Length:534 Identity:227/534 - (42%)
Similarity:307/534 - (57%) Gaps:75/534 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGL-GRQGFKCIQCKLLVHKKCHKLVQKH 546
            |:.|.| |:::::|||.|.|....:..:|::|::.|||: |:||::|..|..:|||:||.|:...
Human   257 RQRAMR-RRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTA 320

  Fly   547 CTDQPE-PLVKERAEESSDPIPVP---------LP-------PLPYEAMSGGAEA--CETHDHAH 592
            ||.|.. ..|..:..|....|.:|         :|       .|.:..|..|.:.  |:.:.|..
Human   321 CTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIR 385

  Fly   593 IVAPPPPE--------------DPLEPG-------------------------------TQRQYS 612
            ..|...|.              ..|:||                               :..:..
Human   386 CQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLG 450

  Fly   613 LNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFL 677
            :::||.|||:|:||:.||::..::.|..:||:||:||.::..|:|::...|||.:...|.|||||
Human   451 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFL 515

  Fly   678 VGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLK 742
            ..|..|||||.|||||:|||.|||||:|:|:.||..|..||||||||..||.|||:|||||||||
Human   516 TQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLK 580

  Fly   743 LDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYE 807
            |||||||||||.||.|:|||||||..|.||:||||||:|||||||:...||.:|||||:||||||
Human   581 LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYE 645

  Fly   808 MLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRE 872
            ||.|.:||:    :||     ||.||:.||...:..|..|...|..:||.|:.|||..|||...:
Human   646 MLCGHAPFE----AEN-----EDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQ 701

  Fly   873 SAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNID 937
            .....|:.|||||.:||..|..:|:.|||:||:.|..|::||.|:|..|...|||.|:..:..|:
Human   702 GGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN 766

  Fly   938 QSEFEGFEYVNPLL 951
            |.||..|.||:|.|
Human   767 QDEFRNFSYVSPEL 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_aPKC 496..550 CDD:410344 23/54 (43%)
STKc_aPKC 620..947 CDD:270740 177/326 (54%)
PRKCHXP_047287541.1 C2_PKC_epsilon 8..122 CDD:175981
C1_nPKC_epsilon-like_rpt1 265..325 CDD:410385 23/59 (39%)
C1_nPKC_epsilon-like_rpt2 343..397 CDD:410388 9/53 (17%)
STKc_nPKC_eta 458..780 CDD:270742 180/330 (55%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.