DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and PRKCE

DIOPT Version :9

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_005391.1 Gene:PRKCE / 5581 HGNCID:9401 Length:737 Species:Homo sapiens


Alignment Length:609 Identity:227/609 - (37%)
Similarity:312/609 - (51%) Gaps:144/609 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   475 DGEDRSI-------YRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWG-LGRQGFKCIQC 531
            |.|:|..       .|:||.| |::::||||.|.|....:..:|::|:|.||| :|:||::|..|
Human   141 DNEERVFRERMRPRKRQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVC 204

  Fly   532 KLLVHKKCHKLVQKHCT-----DQPEPL------------------------------------- 554
            ..:|||:||:|:...|.     :.|:.:                                     
Human   205 TCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQ 269

  Fly   555 ----------VKERAE------------------------------------------ESSDPIP 567
                      |..|.|                                          ||..|..
Human   270 GLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPAS 334

  Fly   568 VPLPPLPYEAMSGGAEAC-----------------ETHDHAHIVAPPPPEDPLEPGTQ------- 608
            ...|.....:.|.....|                 :.....|..|..|....:.||..       
Human   335 GSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQ 399

  Fly   609 -RQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETAS 672
             ::..|::|..|:|:|:||:.||::.||:....:||:||:||.::..|:|:|...|||.:...|.
Human   400 AKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALAR 464

  Fly   673 NHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGII 737
            .||:|..|:.||||..|||||:|:|.|||||:.:||.|:..|..:||||||::.||.|||:.|:|
Human   465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529

  Fly   738 YRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 802
            ||||||||:|||.|||.||.|:|||||||..|.||:||||||:|||||||:..:||.||||||||
Human   530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALG 594

  Fly   803 VLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRL 867
            ||:|||:||:.||         :.:.||.||:.||...:..|..||..|.|:||.|:.|||..||
Human   595 VLMYEMMAGQPPF---------EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRL 650

  Fly   868 GC----HRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPD 928
            ||    :.|.|   |..|||||.:||.|||:|::.||||||:.:.||:.||..:||.|...||..
Human   651 GCVASQNGEDA---IKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLV 712

  Fly   929 DDHVIDNIDQSEFEGFEYVNPLLM 952
            |:.::..|:|.||:||.|....||
Human   713 DEAIVKQINQEEFKGFSYFGEDLM 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_1 498..550 CDD:278556 21/57 (37%)
S_TKc 616..884 CDD:214567 145/271 (54%)
STKc_aPKC 620..947 CDD:270740 174/330 (53%)
PRKCENP_005391.1 C2_PKC_epsilon 3..135 CDD:175981
C1_nPKC_epsilon-like_rpt1 161..224 CDD:410385 26/63 (41%)
Interaction with actin. /evidence=ECO:0000250 223..228 0/4 (0%)
C1_nPKC_epsilon-like_rpt2 241..295 CDD:410388 3/53 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..356 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..398 5/27 (19%)
STKc_nPKC_epsilon 412..732 CDD:270743 175/331 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222529at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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