DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and PRKCB

DIOPT Version :9

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_002729.2 Gene:PRKCB / 5579 HGNCID:9395 Length:673 Species:Homo sapiens


Alignment Length:671 Identity:234/671 - (34%)
Similarity:308/671 - (45%) Gaps:200/671 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   467 PQAPGLSCDGEDRSI--YRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCI 529
            |.|.....:||:.::  .|:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|.
Human     4 PAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQ 68

  Fly   530 QCKLLVHKKCHKLVQKHC--------TDQPEPLVKERAEESSDP--------------------- 565
            .|..:|||:||:.|...|        :|.|....|.:....|.|                     
Human    69 VCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCD 133

  Fly   566 -------------IP-----------------------------------VPLPPL----PY--- 575
                         :|                                   ||:.|.    ||   
Human   134 TCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKL 198

  Fly   576 ----------------------------------------------------------------- 575
                                                                             
Human   199 KLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGI 263

  Fly   576 -----EAMSGGAEACETHDHAHIVAPPPPED----------------------PLEP-------- 605
                 .::.|..:.....:..:...|.|||.                      |.|.        
Human   264 SELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKF 328

  Fly   606 ---GTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHV 667
               |.:.:..|.||..:.|:|:||:.||::.|.:.|..:||:|::||.:|..|:|::....||.|
Human   329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393

  Fly   668 FETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLH 732
            .......|||..|||||||..||:||:|:|.|||||||:|:..|..|.||.||||||::.|.||.
Human   394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458

  Fly   733 EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 797
            .|||||||||||||:||.|||||:.|:|||||.|..|.||.||||||:||||||:..:.||.|||
Human   459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523

  Fly   798 WWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKN 862
            |||.||||||||||::||      |..|   ||.|||.|:|..:..|:|:|..|.::.||.:.|:
Human   524 WWAFGVLLYEMLAGQAPF------EGED---EDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579

  Fly   863 PADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTP 927
            |..||||..|.. .||..|.||:.:|||.||||::.||:||:. ..|:..||...||.....|||
Human   580 PGKRLGCGPEGE-RDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFTRHPPVLTP 642

  Fly   928 DDDHVIDNIDQSEFEGFEYVN 948
            .|..||.||||||||||.:||
Human   643 PDQEVIRNIDQSEFEGFSFVN 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_1 498..550 CDD:278556 24/59 (41%)
S_TKc 616..884 CDD:214567 144/267 (54%)
STKc_aPKC 620..947 CDD:270740 177/326 (54%)
PRKCBNP_002729.2 C1_cPKC_rpt1 35..92 CDD:410383 24/56 (43%)
C1_cPKC_rpt2 102..155 CDD:410386 4/52 (8%)
C2_PKC_alpha_gamma 159..289 CDD:175992 6/129 (5%)
STKc_cPKC_beta 341..663 CDD:270767 179/332 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D143719at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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