Protein Alignment aPKC and PRKCB

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 234/671 - (34%)
• Similarity: 308/671 - (45%)
• Gaps: 200/671 - (29%)

  Fly   467 PQAPGLSCDGEDRSI--YRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCI 529
            |.|.....:||:.::  .|:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|.
Human     4 PAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQ 68

  Fly   530 QCKLLVHKKCHKLVQKHC--------TDQPEPLVKERAEESSDP--------------------- 565
            .|..:|||:||:.|...|        :|.|....|.:....|.|
Human    69 VCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCD 133

  Fly   566 -------------IP-----------------------------------VPLPPL----PY--- 575
                         :|                                   ||:.|.    ||
Human   134 TCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKL 198

  Fly   576 ----------------------------------------------------------------- 575
                                                                             
Human   199 KLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGI 263

  Fly   576 -----EAMSGGAEACETHDHAHIVAPPPPED----------------------PLEP-------- 605
                 .::.|..:.....:..:...|.|||.                      |.|.
Human   264 SELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKF 328

  Fly   606 ---GTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHV 667
               |.:.:..|.||..:.|:|:||:.||::.|.:.|..:||:|::||.:|..|:|::....||.|
Human   329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393

  Fly   668 FETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLH 732
            .......|||..|||||||..||:||:|:|.|||||||:|:..|..|.||.||||||::.|.||.
Human   394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458

  Fly   733 EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 797
            .|||||||||||||:||.|||||:.|:|||||.|..|.||.||||||:||||||:..:.||.|||
Human   459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523

  Fly   798 WWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKN 862
            |||.||||||||||::||      |..|   ||.|||.|:|..:..|:|:|..|.::.||.:.|:
Human   524 WWAFGVLLYEMLAGQAPF------EGED---EDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579

  Fly   863 PADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTP 927
            |..||||..|.. .||..|.||:.:|||.||||::.||:||:. ..|:..||...||.....|||
Human   580 PGKRLGCGPEGE-RDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFTRHPPVLTP 642

  Fly   928 DDDHVIDNIDQSEFEGFEYVN 948
            .|..||.||||||||||.:||
Human   643 PDQEVIRNIDQSEFEGFSFVN 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	24/61 (39%)
		STKc_aPKC	620..947	CDD:270740	177/326 (54%)
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	24/56 (43%)
		C1_cPKC_rpt2	102..155	CDD:410386	4/52 (8%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	6/129 (5%)
		STKc_cPKC_beta	341..663	CDD:270767	179/332 (54%)