Protein Alignment aPKC and PRKCA

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_002728.2
• Gene: PRKCA / 5578
• HGNCID: 9393
• Length: 672
• Species: Homo sapiens
• Alignment Length: 675
• Identity: 240/675 - (35%)
• Similarity: 310/675 - (45%)
• Gaps: 200/675 - (29%)

  Fly   460 ATVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQ 524
            |.|||.....  .|.|..:| ..|:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|
Human     2 ADVFPGNDST--ASQDVANR-FARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQ 63

  Fly   525 GFKCIQCKLLVHKKCHKLVQKHC--------TDQPEP---------------------------- 553
            ||:|..|..:|||:||:.|...|        ||.|..
Human    64 GFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQ 128

  Fly   554 -----------------------------------LVKERAEES-------------------SD 564
                                               |..|.|:|.                   ||
Human   129 GMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSD 193

  Fly   565 P------IPVP------------------------------------------------------ 569
            |      ||.|
Human   194 PYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGS 258

  Fly   570 ----------LP------------------PLPYEAMSGGAEACETHDHAHIVAP------PPPE 600
                      :|                  |:|.....|..|..:..:.|.: .|      .|.|
Human   259 LSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKL-GPAGNKVISPSE 322

  Fly   601 DPLEPGTQ-RQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTE 664
            |..:|... .:..|.||..:.|:|:||:.||::.:.:.|..:||:|::||.:|..|:|::....|
Human   323 DRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVE 387

  Fly   665 KHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALN 729
            |.|.......|||..|||||||..||:||:|:|.|||||||:|:..:..|..|.|||||||:.|.
Human   388 KRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452

  Fly   730 FLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGF 794
            |||::||||||||||||:||.|||||:.|:|||||.:..|.||.||||||:||||||:..:.||.
Human   453 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517

  Fly   795 SVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFL 859
            ||||||.||||||||||:.||         |...||.|||.|:|..:..|:|||..|.||.||.:
Human   518 SVDWWAYGVLLYEMLAGQPPF---------DGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLM 573

  Fly   860 NKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQ 924
            .|:||.||||..|.. .|:..|.||:.:|||.||.:::.|||||:: ..:...||...||.....
Human   574 TKHPAKRLGCGPEGE-RDVREHAFFRRIDWEKLENREIQPPFKPKV-CGKGAENFDKFFTRGQPV 636

  Fly   925 LTPDDDHVIDNIDQSEFEGFEYVNP 949
            |||.|..||.|||||:||||.||||
Human   637 LTPPDQLVIANIDQSDFEGFSYVNP 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	25/59 (42%)
		S_TKc	616..884	CDD:214567	143/267 (54%)
		STKc_aPKC	620..947	CDD:270740	173/326 (53%)
PRKCA	NP_002728.2	C1_1	37..89	CDD:278556	24/51 (47%)
		C1_1	102..154	CDD:278556	0/51 (0%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	11/129 (9%)
		STKc_cPKC_alpha	328..668	CDD:270766	180/345 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920