Protein Alignment aPKC and PRKACG

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 117/337 - (34%)
• Similarity: 186/337 - (55%)
• Gaps: 21/337 - (6%)

  Fly   608 QRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETAS 672
            |...|.:.||.:|.:|.||:.:|::|..:.|...||||::.|..|...:.::.:..||.:.: |.
Human    36 QNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQ-AI 99

  Fly   673 NHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGII 737
            :.||||.|...|:..|.|:.|:|:|.||::...:||..|..|.||.||||::.||:.:||...:|
Human   100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLI 164

  Fly   738 YRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 802
            :||||.:|:|:|.:|::::||:|..|   |....|.|.||||.|:||||:..:.|..:|||||||
Human   165 HRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226

  Fly   803 VLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRL 867
            ||:|||..|..||    .::.|.|     :::.|:...:|.|..||.....:|:..|..:...|.
Human   227 VLIYEMAVGFPPF----YADQPIQ-----IYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRF 282

  Fly   868 GCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHV 932
            | :..:...||.:|.:|....|..:..|:|..||.|:.....|.:|| .::..|.::::
Human   283 G-NLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF-DDYEEEELRIS------ 339

  Fly   933 IDNIDQSEFEGF 944
            |:.....||..|
Human   340 INEKCAKEFSEF 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344
		STKc_aPKC	620..947	CDD:270740	113/325 (35%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	110/303 (36%)