Protein Alignment aPKC and PRKACA

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001291278.1
• Gene: PRKACA / 5566
• HGNCID: 9380
• Length: 427
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 131/372 - (35%)
• Similarity: 202/372 - (54%)
• Gaps: 30/372 - (8%)

  Fly   569 PLPPLPYEAMSGGAEACETHDHAHIVAPPP-----------PEDPL---EPGTQRQYSLNDFELI 619
            |.|.||.|...|.|:: :.:.:.....|.|           .||.|   |...|....|:.||.|
Human    60 PRPGLPREGARGTAKS-QGYKYLGWRRPWPWNVVKEFLAKAKEDFLKKWESPAQNTAHLDQFERI 123

  Fly   620 RVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCF 684
            :.:|.||:.:|::|:.:.|...||||::.|..|...:.|:....||.:.: |.|.||||.|...|
Human   124 KTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQ-AVNFPFLVKLEFSF 187

  Fly   685 QTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLD 749
            :..|.|:.|:|:|.||::..|::|..|..|.|||||||:|.|...:||...:||||||.:|:|:|
Human   188 KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 252

  Fly   750 HEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSP 814
            .:|:|::||:|..|   |....|.|.||||.|:||||:..:.|..:|||||||||:|||.||..|
Human   253 QQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP 314

  Fly   815 FDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIV 879
            |    .::.|.|     :::.|:...:|.|...|.....:|:..|..:...|.| :.::...||.
Human   315 F----FADQPIQ-----IYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG-NLKNGVNDIK 369

  Fly   880 SHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLT 926
            :|.:|...||..:.:::|..||.|:.....|.:|| .::..|.::::
Human   370 NHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF-DDYEEEEIRVS 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344
		STKc_aPKC	620..947	CDD:270740	113/307 (37%)
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	115/303 (38%)