DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and prkchb

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001038271.1	Gene:	prkchb / 556591	ZFINID:	ZDB-GENE-041001-104	Length:	676	Species:	Danio rerio

Alignment Length:	543	Identity:	216/543 - (39%)
Similarity:	301/543 - (55%)	Gaps:	85/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 RSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWG-LGRQGFKCIQCKLLVHKKCHKL 542
            :...|:...:.||::::.||.|.|....:..||.:|::.||| :|:||::|..|..:|||:||.|
Zfish   146 KEFVRKKVLKRRKVHQIYGHKFMATFLPQPTFCYHCKNFIWGVIGKQGYQCQVCTCVVHKRCHAL 210

  Fly   543 VQKHCTDQPEPLVKERAEESS-DPIPVPLP------------------PLPYEAMSGGA------ 582
            |...|     |.:::.|.|.. ....:.||                  .|.|..:..|.
Zfish   211 VVTEC-----PRMRKDANEGQRQGFSINLPHQFKEHNYKVPTYCNHCGSLLYGLVKQGLHCKICK 270

  Fly   583 ----EACETH-------DHAHI------------VAPPPPEDPLEPGTQRQYS------------ 612
                :.||.:       |:|.:            ::....:..|...:.|..|
Zfish   271 MNIHKRCEQNVAPNCGVDNAELASKLSEIGLLNTISKRKSQGSLHMSSVRSQSSTTSIETTEEES 335

  Fly   613 --------LNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFE 669
                    |.||..::|:|:||:.||::..|:...|::|:|::||.::..::|::...|||.|..
Zfish   336 DEEAVKVCLEDFSFLQVLGKGSFGKVMLARLKSDHRVFAVKMLKKDVILQEDDVEATMTEKRVLT 400

  Fly   670 TASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEK 734
            .|..||||..|:.||||..|||||:|||.|||||:|:|:.||..|..|:|||||::.||.|||.|
Zfish   401 LAHQHPFLTQLYYCFQTTERLFFVMEFVNGGDLMFHIQKCRRFDEPRAQFYAAEVTSALKFLHSK 465

  Fly   735 GIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWW 799
            |||||||||||:|||.:||.||.|:|||||.|..|..||||||||:|||||||:.|.||.|||||
Zfish   466 GIIYRDLKLDNILLDRDGHCKLADFGMCKEEIFNGKLTSTFCGTPDYIAPEILQEELYGVSVDWW 530

  Fly   800 ALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPA 864
            ||||||||||:|.:||         :..|||.||:.||:..|.....||..|..:|||.|.::||
Zfish   531 ALGVLLYEMLSGHAPF---------EAETEDELFECILKDEIIYSSWLSYEAEDILKGLLTRDPA 586

  Fly   865 DRLGC-HRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPD 928
            .|||| ..:.....|.:|.||..:|||.|.|:::||||.||::|..|:.||.|:||.|...|||.
Zfish   587 CRLGCIDNDGGEEAITAHAFFTGLDWEKLYRREITPPFTPRINSIEDVNNFDPDFTQEDPCLTPI 651

  Fly   929 DDHVIDNIDQSEFEGFEYVNPLL 951
            ::.:.. ..|..|:.|.|:.|.|
Zfish   652 EESLFP-FHQDGFKDFSYIAPEL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	22/52 (42%)
		S_TKc	616..884	CDD:214567	143/268 (53%)
		STKc_aPKC	620..947	CDD:270740	169/327 (52%)
prkchb	NP_001038271.1	C2_PKC_epsilon	3..133	CDD:175981
		C1_1	165..216	CDD:278556	22/55 (40%)
		C1_1	236..288	CDD:278556	5/51 (10%)
		S_TKc	347..607	CDD:214567	143/268 (53%)
		PKc_like	351..673	CDD:304357	171/331 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920