Protein Alignment aPKC and prkcz

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001025262.1
• Gene: prkcz / 555737
• ZFINID: ZDB-GENE-070511-1
• Length: 599
• Species: Danio rerio
• Alignment Length: 542
• Identity: 358/542 - (66%)
• Similarity: 424/542 - (78%)
• Gaps: 44/542 - (8%)

  Fly   449 LQSEEEIEPAYAT------------VFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQ 501
            :.|:.|:|.|:..            |||::|:.||:.|.|||:|||||||||||||||||||:||
Zfish    70 ISSQMELEEAFRIYSRSRHSGLLLHVFPSIPEKPGMPCPGEDKSIYRRGARRWRKLYRVNGHLFQ 134

  Fly   502 AKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLV----QKH---CTDQPEPLVKERA 559
            ||||||:|:|.:|.:|||||||||:|||.|||||||:|||||    |:|   .....||||.:
Zfish   135 AKRFNRKAYCGHCSERIWGLGRQGYKCINCKLLVHKRCHKLVPLTCQRHMDPVMPSQEPLVDD-- 197

  Fly   560 EESSDPIPVPLP---------PLPYEAMSGGAEACE--THDHAHIVAPPPPEDPLEPGTQ--RQY 611
            ::|.:.:.:| |         |:|:.|.:...|..|  :.|...:|      |.:| |.|  :..
Zfish   198 DKSGEEVELP-PEDPEDTDAIPVPFLAHNRKVEKAEDDSEDLKAVV------DGIE-GIQISQCL 254

  Fly   612 SLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPF 676
            .|.||:||||||||||||||:|.|::..:||||||:||.||.||||||||||||||||.||.:||
Zfish   255 GLGDFDLIRVIGRGSYAKVLLVRLKKNEQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPF 319

  Fly   677 LVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDL 741
            ||||||||||.||||.|||:|.|||||:||||||:|||||||||||||.:|||||||||||||||
Zfish   320 LVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDL 384

  Fly   742 KLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLY 806
            ||||||||.:|||||||||||||||||||||||||||||||||||||||||||||||||||||::
Zfish   385 KLDNVLLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMF 449

  Fly   807 EMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHR 871
            ||:|||||||:  .::|||.|||:|||||||||.|||||||||:|||||||||||:|.:||||..
Zfish   450 EMMAGRSPFDI--ITDNPDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQV 512

  Fly   872 ESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNI 936
            ::.|.||.||.||:::||:.||:|||||||||::..|..|.||..:||.|.|||||||:.||..|
Zfish   513 QTGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLENFDTQFTNEPVQLTPDDEDVIKRI 577

  Fly   937 DQSEFEGFEYVNPLLMSLEDCV 958
            ||||||||||:||||:|.|:.|
Zfish   578 DQSEFEGFEYINPLLLSTEETV 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	40/60 (67%)
		STKc_aPKC	620..947	CDD:270740	257/326 (79%)
prkcz	NP_001025262.1	PB1	16..98	CDD:413452	6/27 (22%)
		C1_aPKC_zeta	129..183	CDD:410448	39/53 (74%)
		STKc_aPKC_zeta	243..599	CDD:270768	273/358 (76%)