DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and prkci

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001012707.1	Gene:	prkci / 503517	XenbaseID:	XB-GENE-481945	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	360/538 - (66%)
Similarity:	409/538 - (76%)	Gaps:	50/538 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 LQSEEEIEPAYAT------------VFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQ 501
            :.|:.|:|.|:..            |||.:|:.||:.|.|||:||||||||||||||..|||.||
Frog    73 VSSQLELEEAFRLYELNKDSELLIHVFPCIPERPGMPCAGEDKSIYRRGARRWRKLYCANGHTFQ 137

  Fly   502 AKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPI 566
            ||||||||.||.|.||||||||||:|||.|||||||||||||...|              ....|
Frog   138 AKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVSIEC--------------GRHTI 188

  Fly   567 PVPLPPLPYEAMSGGAEACETHDHAHIVAP--PPPEDPL-------------EPG-TQRQYSLND 615
            ..|:.|:....|..        ||:.. .|  |..:|.|             |.| |.....|.|
Frog   189 AEPVIPMDPPGMHS--------DHSEPXLPYRPRSQDNLDQVGEEKEAMNSRESGKTPSSLGLQD 245

  Fly   616 FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGL 680
            |:|:||||||||||||:|.|::|.|||||||:||.||.||||||||||||||||.||||||||||
Frog   246 FDLMRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGL 310

  Fly   681 HSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDN 745
            ||||||.||||||||:|.|||||:||||||:|||||||||:||||||||:|||:|||||||||||
Frog   311 HSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDN 375

  Fly   746 VLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLA 810
            ||||.|||||||||||||||:||||||||||||||||||||||||||||||||||||||::||:|
Frog   376 VLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMA 440

  Fly   811 GRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAF 875
            ||||||:.|:|:||||||||:||||||||.|||||||||:||||||.||||:|.||||||.::.|
Frog   441 GRSPFDIVGSSDNPDQNTEDFLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKDRLGCHPQTGF 505

  Fly   876 MDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSE 940
            .||..|.||:|:||:|:|:|||.|||||.:..:..|.||..:||.|.|||||||:.|:..|||||
Frog   506 ADIQGHQFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPVQLTPDDEDVVRKIDQSE 570

  Fly   941 FEGFEYVNPLLMSLEDCV 958
            ||||||:||||||.|:||
Frog   571 FEGFEYINPLLMSAEECV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	41/51 (80%)
		S_TKc	616..884	CDD:214567	225/267 (84%)
		STKc_aPKC	620..947	CDD:270740	262/326 (80%)
prkci	NP_001012707.1	PB1_aPKC	19..101	CDD:99725	6/27 (22%)
		C1_1	134..186	CDD:278556	41/65 (63%)
		STKc_aPKC_iota	225..588	CDD:270769	277/362 (77%)
		S_TKc	246..514	CDD:214567	225/267 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	466	1.000	Domainoid score	I461
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37667
Inparanoid	1	1.050	822	1.000	Inparanoid score	I458
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003559
OrthoInspector	1	1.000	-	-		otm47434
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2434
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050