Protein Alignment aPKC and Akt

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 188/567 - (33%)
• Similarity: 289/567 - (50%)
• Gaps: 95/567 - (16%)

  Fly   419 IHYERLPIPVPIPTVPMGVAPSSQQMS-QHQLQSEEEIEPAY-------ATVF----PNVPQAPG 471
            |.|.:...|...||     :.|:::.| |....|.....|.:       .|.|    |:|.....
  Fly    41 IIYSQSTHPNSSPT-----SGSAEKFSWQQSWPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHA 100

  Fly   472 LSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQ------------ 524
            |:   |...:.:.|   |  |.:...||   |.:.:|.|..:...|:.|...:
  Fly   101 LT---EQTQVVKEG---W--LMKRGEHI---KNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFL 154

  Fly   525 --GFKCIQCKLLVHKKCHKLVQKHCTDQPEP-----------------------LVKERAEESSD 564
              .|....|:::.            .|:|:|                       |.:::..|:..
  Fly   155 LNNFTVRGCQIMT------------VDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIR 207

  Fly   565 PIPVPLPPLPYEAMSGGAEACETH-DHAHIVAPPPPEDPLEPGTQ------RQYSLNDFELIRVI 622
            .:...|..:...||:...:...|. |.|.|......|.....||.      ::.:|.:||.::|:
  Fly   208 NVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVL 272

  Fly   623 GRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTP 687
            |:|::.||::...:.|.::||:|::||.::...:::....||..|.: ::|||||:.|...|||.
  Fly   273 GKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTN 336

  Fly   688 SRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEG 752
            .||.||:::|.||:|.:|:..:|...|:..|||.|||..||.:||.:|||||||||:|:|||.:|
  Fly   337 DRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDG 401

  Fly   753 HIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDL 817
            |||:.|:|:|||.|..|.||.||||||.|:|||:|...|||.:||||..||::|||:.||.||
  Fly   402 HIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF-- 464

  Fly   818 AGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHP 882
                .|.|   .|.||.:||.:.::.||:::..|.::|.|.|.|:|..|||..::.. .:|.:||
  Fly   465 ----YNRD---HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDV-KEIQAHP 521

  Fly   883 FFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDD 929
            ||.:::|..|..|::.|||||::.||.|...|..|||||:|:|||.|
  Fly   522 FFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	9/67 (13%)
		STKc_aPKC	620..947	CDD:270740	142/310 (46%)
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	17/128 (13%)
		STKc_PKB	270..590	CDD:270723	142/310 (46%)