DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and akt2l

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	XP_021334818.1	Gene:	akt2l / 403146	ZFINID:	ZDB-GENE-040121-5	Length:	625	Species:	Danio rerio

Alignment Length:	436	Identity:	156/436 - (35%)
Similarity:	250/436 - (57%)	Gaps:	49/436 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 FKCIQCKLLVHKKCHKLVQKHCTDQPEP-----------LVKERA--EESSDPIPVPLPPLPYEA 577
            |...:|:|:.            |::|.|           .|.||.  .:|||.....:..:  :.
Zfish    55 FSVEECQLMK------------TERPRPNTFMIRCLQWTTVIERTFHVDSSDERDEWMRAI--QM 105

  Fly   578 MSGGAEACETHDHAHIVAPPPPEDPLE------PGTQRQYSLNDFELIRVIGRGSYAKVLMVELR 636
            ::.|.:|.:. |....:....|.|.||      ..:..:.::|||:.::::|:|::.||::|..:
Zfish   106 VANGLQARDV-DEPMEIKYSSPSDALEDMEMCLSKSSSRVTMNDFDYLKLLGKGTFGKVILVREK 169

  Fly   637 RTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGD 701
            .:...||||:::|.::...:::....||..|.:. :.||||..|...|||..||.||:|:..||:
Zfish   170 ASGMYYAMKILRKEVIIAKDEVAHTVTESRVLQN-TRHPFLTTLKYAFQTHDRLCFVMEYANGGE 233

  Fly   702 LMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGI 766
            |.:|:.|:|...|:.||||.|||..||::.|.:.::||.|||:|::||::||||:||:|:|||||
Zfish   234 LFFHLSRERVFSEDRARFYGAEIVSALDYPHSQNVVYRHLKLENLMLDNDGHIKITDFGLCKEGI 298

  Fly   767 RPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDY 831
            ....|..||||||.|:|||:|...|||.:||||.|||::|||:.||.||           .::|:
Zfish   299 TDEATMRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF-----------YSQDH 352

  Fly   832 --LFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLER 894
              ||:.|:.:.||.|||||..|.::|.|.|.|.|..|||...:.| .|::.|.||..:.|:.:.:
Zfish   353 ERLFEQIVMEEIRFPRSLSTHARALLTGLLRKEPKQRLGGGPDDA-RDVMMHKFFSGVQWDDVLQ 416

  Fly   895 KQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSE 940
            |::.|||||::.|:.|...|..|||.:::.:||.|.....::::.|
Zfish   417 KKLLPPFKPQVTSETDTRYFDDEFTAQSITVTPPDKLSCQDVEEPE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	4/23 (17%)
		S_TKc	616..884	CDD:214567	116/269 (43%)
		STKc_aPKC	620..947	CDD:270740	134/323 (41%)
akt2l	XP_021334818.1	PH_PKB	4..111	CDD:269947	13/69 (19%)
		PKc_like	153..462	CDD:328722	133/321 (41%)
		PKc_like	<423..551	CDD:328722	13/40 (33%)
		S_TK_X	553..621	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910