Protein Alignment aPKC and prkcbb

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_957272.1
• Gene: prkcbb / 393953
• ZFINID: ZDB-GENE-040426-1178
• Length: 670
• Species: Danio rerio
• Alignment Length: 671
• Identity: 230/671 - (34%)
• Similarity: 310/671 - (46%)
• Gaps: 201/671 - (29%)

  Fly   475 DGEDRS-----IYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLL 534
            |||:||     ..|:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|..|..:
Zfish     8 DGEERSAPMRGFARQGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFV 72

  Fly   535 VHKKCHKLVQKHC--------TDQPEPLVKERAEESSDP-------------------------- 565
            |||:||:.|...|        :|.|....|.:....|.|
Zfish    73 VHKRCHEFVTFSCPGADKGPASDDPRSKHKFKVHTYSSPTFCDHCGSLLYGLIHQGMRCDHCMMN 137

  Fly   566 --------IP-----------------------------------VPLPPL----PY-------- 575
                    :|                                   ||:.|.    ||
Zfish   138 IHKRCVANVPSLCGTDHTERRGRIQITAEIKNNVLTVSIKEAKNLVPMDPNGLSDPYVKLKLIPD 202

  Fly   576 -------------------------------------------------------------EAMS 579
                                                                         |...
Zfish   203 PKSESKQKTKTIKCCLNPTWNETFTFNLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 267

  Fly   580 GGAE------ACETHDHAHIVAPPPPEDPLEP-----------------------------GTQR 609
            .|.:      :.|..::.::..||..|:..|.                             |.:.
Zfish   268 QGVDGWFKLLSQEEGEYFNVPVPPEGEEGNEELRQKFERAKIGPSKTDGSSSNAISKFDSNGNRD 332

  Fly   610 QYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNH 674
            :..|:||..:.|:|:||:.||::.|.:....::|:|::||.:|..|:|::....||.|...:...
Zfish   333 RMKLSDFNFLMVLGKGSFGKVMLAERKGADELFAIKILKKDVVIQDDDVECTMVEKRVLALSGKP 397

  Fly   675 PFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYR 739
            |||..|||||||..||:||:|::.|||||||:|:..:..|.||.||||||::.|.|||.||:|||
Zfish   398 PFLTQLHSCFQTMDRLYFVMEYINGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHSKGVIYR 462

  Fly   740 DLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVL 804
            |||||||:||.|||||:.|:|||||.:..|.||.||||||:||||||:..:.||.||||||.|||
Zfish   463 DLKLDNVMLDAEGHIKIADFGMCKENMLDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 527

  Fly   805 LYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGC 869
            |||||||:.||         |...||.|||.|:|..:..|:|:|..|.::.||.:.|:|..||||
Zfish   528 LYEMLAGQPPF---------DGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGC 583

  Fly   870 HRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVID 934
            ..|.. .||..|.||:.||||.||.::|.|||||:. ..||..||...||.....|||.|..||.
Zfish   584 GPEGE-RDIREHGFFRYMDWEKLEHREVQPPFKPKA-CGRDAENFDRFFTRHPPVLTPPDQEVIM 646

  Fly   935 NIDQSEFEGFEYVNPLLMSLE 955
            |:||.|||||.::||...::|
Zfish   647 NLDQDEFEGFSFINPEFPAME 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	24/59 (41%)
		S_TKc	616..884	CDD:214567	138/267 (52%)
		STKc_aPKC	620..947	CDD:270740	171/326 (52%)
prkcbb	NP_957272.1	C1_1	36..88	CDD:278556	24/51 (47%)
		C1_1	101..151	CDD:278556	4/49 (8%)
		C2_PKC_alpha_gamma	158..288	CDD:175992	8/129 (6%)
		STKc_cPKC_beta	338..660	CDD:270767	173/332 (52%)
		S_TKc	339..597	CDD:214567	138/267 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920