Protein Alignment aPKC and Pdk1

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001261183.1
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 645
• Identity: 145/645 - (22%)
• Similarity: 242/645 - (37%)
• Gaps: 176/645 - (27%)

  Fly   380 LNGCGGGSIAGGSIGGRSSVLGTIHNGHGHHHQQYHHECIHYERLPIPVPIPTVPMGVAPSSQQM 444
            |.|.|...||..::...:|..|...:.:|..|||:.:                :....|.|:.:.
  Fly    32 LPGSGASGIAAAAVITVASDCGENCSSNGTEHQQHFN----------------IATTTATSATEA 80

  Fly   445 SQHQLQSEEEIEPAYATV------FPNV----------------PQAPGLSCDGEDRSIYRRGAR 487
            :...:..|:    |.|||      |.::                .|.....|.....:.....:|
  Fly    81 TMPAMAKEK----ASATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSR 141

  Fly   488 RWRKLYRVNGHIFQ-----AKRFNRRAFCAYC-----------QDRIWGLGRQGFKCIQCKLLVH 536
            .....|..|||...     |...:..|...:|           |:.|    ||..:.:......|
  Fly   142 YGSSKYLTNGHTSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDI----RQQTEILDMLRQQH 202

  Fly   537 KKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPED 601
            ::.::..|:    |.:|..::..::..:                     ::.....:..|.|...
  Fly   203 QQGYQSQQQ----QQQPQQQQEQQQQQE---------------------QSQQQQQLQNPAPRRS 242

  Fly   602 PLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKH 666
            |           |||...|.||.|||:.|.:.....:||.||:||.:|.|:..:...|:::.|:.
  Fly   243 P-----------NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKRERE 296

  Fly   667 VFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFL 731
            |....:|.|..|.|...||....|:||:.:.|.||::.::.|.........|.||||:.||...:
  Fly   297 VMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHM 361

  Fly   732 HEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCK--------------------------------- 763
            |.:.:::||||.:|:|||.:.|..:.|:|..|
  Fly   362 HRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLE 426

  Fly   764 -----------EGIRPGD---------------------TTSTFCGTPNYIAPEILRGEDYGFSV 796
                       |.:..||                     ..::|.||..|::||:|:......:.
  Fly   427 NEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAA 491

  Fly   797 DWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDY-LFQVILEKTIRIPRSLSVRAASVLKGFLN 860
            |.||||.::|:|:||..||          :.:.|| :|:.||:..:..|:.....|..:::..|.
  Fly   492 DLWALGCIVYQMIAGLPPF----------RGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLR 546

  Fly   861 KNPADRLGCHRESAFMD-IVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFT 919
            .:|.||||...|..:.: |.:||||..:||:.| |:|..||..|.|.......:|...:|
  Fly   547 VDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTL-RQQTPPPIYPYLPGVSQDEDFRSSYT 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	10/67 (15%)
		S_TKc	616..884	CDD:214567	90/334 (27%)
		STKc_aPKC	620..947	CDD:270740	102/367 (28%)
Pdk1	NP_001261183.1	STKc_PDK1	244..571	CDD:270733	92/336 (27%)
		S_TKc	246..571	CDD:214567	90/334 (27%)
		PH_PDK1	658..764	CDD:241293

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100