Protein Alignment aPKC and akt2

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_937789.1
• Gene: akt2 / 378972
• ZFINID: ZDB-GENE-031007-5
• Length: 479
• Species: Danio rerio
• Alignment Length: 501
• Identity: 175/501 - (34%)
• Similarity: 275/501 - (54%)
• Gaps: 74/501 - (14%)

  Fly   481 IYRRG--ARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQ----GFKCIQCKLLVHKKC 539
            :::||  .:.||..|      |..|  :..:|..|.:........|    .|...:|:|:.
Zfish    12 LHKRGEYIKTWRPRY------FILK--SDGSFIGYKEKPETSDANQPPLNNFSVAECQLMK---- 64

  Fly   540 HKLVQKHCTDQPEP-----------LVKERA------EESSDPIPVPLPPLPYEAMSGGAEACET 587
                    |::|.|           .|.||.      .|..:.|..      .:|::.|.::.|.
Zfish    65 --------TERPRPNTFVIRCLQWTTVIERTFHVDSNSEREEWIRA------IQAVANGLKSREE 115

  Fly   588 HDHAHIVAPPPPEDPLE------PGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKV 646
            .:...|....|.::.||      ..::.:.:::||:.::::|:|::.||::|..:.|...||||:
Zfish   116 DEPMDINFGSPGDNSLEGMEAAITKSRTKVTMSDFDYLKLLGKGTFGKVILVREKATGMYYAMKI 180

  Fly   647 IKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRR 711
            ::|.::...:::....||..|.:. :.||||..|...|||..||.||:|:..||:|.:|:.|:|.
Zfish   181 LRKEVIIAKDEVAHTITESRVLQN-TRHPFLTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERV 244

  Fly   712 LPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFC 776
            ..|:.||||.|||..||.:||.|.::||||||:|::||.:||||:||:|:|||||....|..|||
Zfish   245 FTEDRARFYGAEIVSALEYLHSKDVVYRDLKLENLMLDKDGHIKITDFGLCKEGITNEATMKTFC 309

  Fly   777 GTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTI 841
            |||.|:|||:|...|||.:||||.|||::|||:.||.||      .|.|   .:.||::||.:.|
Zfish   310 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HERLFELILMEEI 365

  Fly   842 RIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLD 906
            |.||:||..|.::|.|.|.|:|..|||...|.| .::::|.||.||:|:.:.:|::.|||||::.
Zfish   366 RFPRNLSPEAKALLAGLLKKDPKQRLGGGPEDA-KEVMTHKFFNNMNWQDVLQKKLVPPFKPQVT 429

  Fly   907 SDRDLANFPPEFTGEAVQLTPDDDHVIDNID------QSEFEGFEY 946
            |:.|...|..|||.:.:.:||.|.:  |::|      ::.|..|.|
Zfish   430 SETDTRYFDDEFTAQTITVTPPDQY--DSLDAEDPDTRTHFSQFSY 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	9/57 (16%)
		STKc_aPKC	620..947	CDD:270740	145/333 (44%)
akt2	NP_937789.1	PH_PKB	4..111	CDD:269947	23/124 (19%)
		STKc_PKB_beta	154..476	CDD:173686	145/333 (44%)