DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and inaC

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	699	Identity:	218/699 - (31%)
Similarity:	311/699 - (44%)	Gaps:	214/699 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 ATVF-PNVPQA--------------PG--LSCDGEDRSI------YRRGARRWRKLYRVNGHIFQ 501
            |||. |:||.|              ||  |...||...:      .|:||.:.:.|..||||.|.
  Fly    11 ATVLPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFG 75

  Fly   502 AKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLV-----------------QKH--- 546
            .:.|....:|.:|:|.|||.|:|||:|.:|:..:|:||.|.|                 .||
  Fly    76 VRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWI 140

  Fly   547 -------------------------------------CTDQPEPL-------------------- 554
                                                 |.:...|:
  Fly   141 STTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKG 205

  Fly   555 ------VKERA-------EESSDP-IPVPLPP--------------------------------- 572
                  :||.|       ...||| |.|.:.|
  Fly   206 NNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQD 270

  Fly   573 ------------------------------LPYEAMSGGAEACETHDHAHIVAP----------- 596
                                          |..|.:.|..:.....:..|...|
  Fly   271 RDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARL 335

  Fly   597 --------PPPEDPLEPGTQRQYSLN--------DFELIRVIGRGSYAKVLMVELRRTRRIYAMK 645
                    .|.|..........::::        ||..::|||:||:.|||:.|.|.|..:||:|
  Fly   336 RDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVK 400

  Fly   646 VIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQR 710
            |::|.::...:|::....||.:...:...||||.:||||||..|||||:|:.:|||||||||:..
  Fly   401 VLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYG 465

  Fly   711 RLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTF 775
            |..|..|.|||.|:::||.||||:.||||||||||:|||.|||:||.|:|:.|||:....||.||
  Fly   466 RFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTF 530

  Fly   776 CGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKT 840
            ||||||:||||:..:.|..:.|||:.||||:|.:||::||      |..|:.|   :|:.|.:|.
  Fly   531 CGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPF------EGDDETT---VFRNIKDKK 586

  Fly   841 IRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRL 905
            ...|:..||.|..::..||.|.|.:|||..| .|..:|.:||||:|:||:..|..::.||.||.:
  Fly   587 AVFPKHFSVEAMDIITSFLTKKPNNRLGAGR-YARQEITTHPFFRNVDWDKAEACEMEPPIKPMI 650

  Fly   906 DSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSL 954
            ...:|::||...||.|...|||.|...:.|:||::|.||.::||..:::
  Fly   651 KHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFITI 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	23/108 (21%)
		S_TKc	616..884	CDD:214567	130/267 (49%)
		STKc_aPKC	620..947	CDD:270740	155/326 (48%)
inaC	NP_476863.1	C1_1	72..124	CDD:278556	20/51 (39%)
		C1_1	137..189	CDD:278556	3/51 (6%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	13/129 (10%)
		S_TKc	371..629	CDD:214567	130/267 (49%)
		STKc_PKC	375..692	CDD:270722	155/326 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452317
Domainoid	1	1.000	296	1.000	Domainoid score	I225
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000