DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and Pkn

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	248/930 - (26%)
Similarity:	361/930 - (38%)	Gaps:	278/930 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 SHSHHGSAHGSLGCLQGGVGVGVGTGSTGSIGMMSAGHIDTGDYDVPHPHPYTHHYMQTTASVTP 261
            :|.|.|||             |.|:..|||..|:..|..|:                ::..|.||
  Fly   665 NHVHMGSA-------------GSGSSLTGSSPMVVGGSRDS----------------ESPISRTP 700

  Fly   262 PHTSL--SRPGSAGAVCQGHDSGSDSSQGCGGSIMGGMLVMGHPGHMGSLGHH--SAGSGSLGRC 322
            ...:|  ..|.:.|...|..:...|:               |...|:.:.|.:  .|.||..|..
  Fly   701 SSDALVEPEPYTPGEQAQNLEFDPDA---------------GINEHVETPGEYPDPAASGLSGMR 750

  Fly   323 SSRCHNTN-TTTTDDSGGGSSGGGGVPGTMSSASMAVGMPGMLMDYHHSHHSGSAGSGLNGCGGG 386
            ....|... :....:|...::|..|.|.|:|     :.|||           .|.|..:.   ||
  Fly   751 PLSMHMQGISVLPPESPPVATGAAGRPNTLS-----LQMPG-----------ASKGQVIQ---GG 796

  Fly   387 SIAG----------------------------------GSIGGRSSVL-------------GTIH 404
            ..|.                                  ..:..|.:.|             |.:.
  Fly   797 RTAAPTTAPPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALE 861

  Fly   405 N------------------GHGHHHQQYHHE--------CIHYERLPIPVPIPTV---------- 433
            |                  ......||:...        |:. :|.|.....||:
  Fly   862 NLLLQQQQTEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVK-QREPAEQTSPTLANQTPTFPPL 925

  Fly   434 -------PMGVAPSSQQMSQH---QLQSEEEIEPAYATVFPNVPQA-------------PGLSCD 475
                   .:...|...|...|   |||.:.. .||.....|..|.|             |.:...
  Fly   926 ASNQIMPSLNARPCQSQSPNHNEFQLQPQPP-HPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLG 989

  Fly   476 G--EDRSI-------YRRGARRWRKLYRVNGHIFQAKRFNRRAFCA---YCQDRIWGLGRQGFKC 528
            |  ||||:       |......:  |||.:......:..:..:..|   :|.:.|..||
  Fly   990 GREEDRSVPPSPLVEYPEDDDEY--LYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQLG------ 1046

  Fly   529 IQCKLLVHKKCHKLVQKHCTDQPEPLVKERA----------------------EESSDPIPVPLP 571
               ||.|...     |:....|..|:::|.|                      :|...|...|:.
  Fly  1047 ---KLYVGSS-----QQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIY 1103

  Fly   572 PLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQ-------------------------- 610
            ...||.....|.|.     |.:.:|...........|:|
  Fly  1104 ANQYELNVAKAAAA-----ASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQP 1163

  Fly   611 -----YSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFET 670
                 .|:::|.|:.|:|||.:.||::.:||...:.||:|.:||..:...::::.:.:||.:||.
  Fly  1164 PNAGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEV 1228

  Fly   671 AS--NHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHE 733
            |:  .|||||.|:|||||...:.||:|:..|||||.|:.....| |..|.||||.:.|.|.:|||
  Fly  1229 ANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFL-EPRAVFYAACVVLGLQYLHE 1292

  Fly   734 KGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDW 798
            ..||||||||||:|||.||::|:.|:|:||||:..||.|.||||||.::|||:|....|..:|||
  Fly  1293 NKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDW 1357

  Fly   799 WALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNP 863
            |.||||::|||.|.|||        |..:.|: :|..|:...:|.||.||:.|.:|::..|.|||
  Fly  1358 WGLGVLIFEMLVGESPF--------PGDDEEE-VFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNP 1413

  Fly   864 ADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPD 928
            ..|||.....| .|:....||:::.|:.|..::|.|||.|.::...|::||..|||.|..||||.
  Fly  1414 ERRLGSSERDA-EDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPP 1477

  Fly   929 DD--HVIDNIDQSEFEGFEY 946
            .:  |:.:. :|..|:.|.|
  Fly  1478 KEPRHLTEE-EQLLFQDFSY 1496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	9/54 (17%)
		S_TKc	616..884	CDD:214567	123/269 (46%)
		STKc_aPKC	620..947	CDD:270740	146/331 (44%)
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012
		HR1_PKN_2	243..309	CDD:212013
		HR1_PKN_3	340..414	CDD:212015
		C2	530..611	CDD:301316
		STKc_PKN	1174..1499	CDD:270741	148/335 (44%)
		S_TKc	1174..1433	CDD:214567	123/269 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27201at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950