Protein Alignment aPKC and prkcda

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_999873.1
• Gene: prkcda / 334571
• ZFINID: ZDB-GENE-030131-6503
• Length: 684
• Species: Danio rerio
• Alignment Length: 594
• Identity: 204/594 - (34%)
• Similarity: 292/594 - (49%)
• Gaps: 127/594 - (21%)

  Fly   446 QHQLQSEEEIEPAYATVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAF 510
            :|.:.:.|||              |.|:        .||||.:..|::.:..|.|.|..|.:..|
Zfish   130 RHSVVANEEI--------------PTLN--------RRRGAIKQAKIHFIKNHEFIATFFRQPTF 172

  Fly   511 CAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCT------------------DQPE----- 552
            |:.|:|.:|||.:||:||.||...:||||...:...||                  |.|.
Zfish   173 CSVCRDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTMFQKERFKIDMPHRFKTN 237

  Fly   553 ----------------PLVKE-------------------------------------------- 557
                            .|||:
Zfish   238 NYMSPTFCDHCGSLLWGLVKQGLKCEDCSMNVHHKCQTKVANLCGINQKLLAEALTQVSTKSSTK 302

  Fly   558 RAEESSDPIPVPLPPLPYEAM--SGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIR 620
            |.:.::..:.|      |:..  |.|.:..:...:.||.....|..|.....|.:.:...|...:
Zfish   303 RPDNNTQDVGV------YQDFNKSPGPDVTDGTPYGHIWEGSSPRPPSRITHQTRITAEHFIFHK 361

  Fly   621 VIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQ 685
            |:|:||:.|||:.||:.|...:|:|.:||.:|..|:|::....||.|...|.::|||..|:|.||
Zfish   362 VLGKGSFGKVLLAELKGTGEWFAVKALKKDVVLMDDDVECTMVEKRVLALAWDNPFLTHLYSTFQ 426

  Fly   686 TPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDH 750
            |...||||:|::.|||||:|:|.:.|.....|.||||||...|.|||.|||||||||||||:||.
Zfish   427 TKEHLFFVMEYLNGGDLMFHIQEKGRFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDG 491

  Fly   751 EGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPF 815
            :||||:.|:|||||.:...:..:||||||:|||||||.|:.|.||||||:.|||:||||.|:|||
Zfish   492 DGHIKIADFGMCKENVFGDNRATTFCGTPDYIAPEILLGQQYSFSVDWWSFGVLVYEMLIGQSPF 556

  Fly   816 DLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVS 880
                     ..:.||.||:.|...|...||.:.:....:|:....::|:.|||     ...:|..
Zfish   557 ---------HGDDEDELFESIRMDTPHYPRWILLDTRDMLERLFERDPSRRLG-----IVGNIRG 607

  Fly   881 HPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFE 945
            |.|||.::|..||.::|.|||||::.:..|.:||..||..|..:|:..:..:||::||..|.||.
Zfish   608 HSFFKTVNWAALEGREVDPPFKPKVKAPNDCSNFDREFLSEKPRLSHCEKGLIDSMDQCAFAGFS 672

  Fly   946 YVNPLLMSL 954
            ::||.:..|
Zfish   673 FINPKMEHL 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	23/71 (32%)
		STKc_aPKC	620..947	CDD:270740	151/326 (46%)
prkcda	NP_999873.1	C1_nPKC_theta-like_rpt1	153..213	CDD:410384	24/59 (41%)
		C1_nPKC_theta-like_rpt2	232..281	CDD:410387	3/48 (6%)
		STKc_nPKC_delta	361..676	CDD:173710	151/328 (46%)