DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	1074	Identity:	280/1074 - (26%)
Similarity:	382/1074 - (35%)	Gaps:	373/1074 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSPRRLTQCAPLPVNIVQQEEEEEQPCLPQQQQHQQTQQQQQS----------QT---------- 59
            :||.:....|......:.:..::||....||||.||.|||||.          ||
  Fly  1050 KSPEQQQATAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQLIDTAATLVPQTETKTKLTEAA 1114

  Fly    60 ---------CPSTPSANQQGSGNLCYSPTCRSRCSSPCPGSPCGSITPPPPPMLTSSQQHLHSNK 115
                     .|:|......|..|:     .:.:.::|...:...:...|.....|.:...|..:.
  Fly  1115 EPTGKSKVQSPNTTKPKSAGKTNV-----GKKKAATPAAAAAAAAAAAPAAATATEAVTALSESN 1174

  Fly   116 NCPA-AQQLMTHLDYAARRQS--------LDQLDSPQSKYFDIQANQLSDIMCRG---------- 161
            ..|. |.|.:|.....|.:.|        |.|....|.:....||...|.....|
  Fly  1175 VTPINADQFITLAPTKAAKTSPNKQQALQLQQQHEEQQRQQQQQATNASSPAATGDATTTPTTIT 1239

  Fly   162 -----------AVVSSIQ---------------SANNTLTRGVSMHSRS---------------- 184
                       |||:|..               |:||:...||..:...
  Fly  1240 IGVAAVNVAAVAVVASAAAAAATDAAADATTSLSSNNSCGEGVGNNLSKFATVSNLAQCLRDVDA 1304

  Fly   185 -------GSAHGSHHGSHHSHSHHGSAHGSLGCLQGGVGVGVGTGSTGSIGM------------- 229
                   .||..|...........||:......:.|...:        |..|
  Fly  1305 ELDDYIPSSAENSQEDDDDDDDGSGSSSDDYSSVDGCANL--------SASMKKKLRKEKKKQKA 1361

  Fly   230 MSAGHIDTGDYDVPH-------------------------PHPYTHHYMQTTASVTPPHTSLSRP 269
            .:|...:...:| ||                         |.|.........:.......|.|..
  Fly  1362 KAAAAAEAKRFD-PHKKIKIDTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEE 1425

  Fly   270 GSAGAVCQGHDSGSDSSQGCGGSIMGGMLVMGHPGHMGSLGHHSAGSGSLGRCS--SRCHNTNTT 332
            ||.|::    |..||...|               |...|....||.|..|...:  ::..::|.|
  Fly  1426 GSGGSL----DEDSDDESG---------------GEECSSTSSSASSEDLDAVAMVTKAGSSNAT 1471

  Fly   333 TTDDSGGGSSGGGGVPGTMSSASMAVGMPGMLMDYHHSHHSGSAGSGLNGCGGGSIAGGSIGGRS 397
            |..||   |:..|...||:|       :|             |||||..|       |.|.....
  Fly  1472 TVLDS---SNSSGSNAGTLS-------VP-------------SAGSGSGG-------GASTSSSP 1506

  Fly   398 SV--LGTIHNGHGHHHQQYHHECIHYERLPIPVPIPTVPMGVAPSSQQMSQHQLQSEEEIEPAYA 460
            |:  :.|..|..|...                        |.||||         .::.:|.:|
  Fly  1507 SIIRMSTCSNDSGFEG------------------------GTAPSS---------PKKMLETSY- 1537

  Fly   461 TVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQG 525
                                                               .|.|
  Fly  1538 ---------------------------------------------------TYSQ---------- 1541

  Fly   526 FKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDH 590
                             .||                 |.....|...:|
  Fly  1542 -----------------FQK-----------------SGRFTAPATVIP---------------- 1556

  Fly   591 AHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDD 655
                            ..:.||::||..:.|:|:||:.|||:.|||.|...||:|.:||.:|.:|
  Fly  1557 ----------------RFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLED 1605

  Fly   656 EDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFY 720
            :|:|....|:.|....:.||:|..|...|||.|.||||:|::.|||||:|:|...|..||.||||
  Fly  1606 DDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFY 1670

  Fly   721 AAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPE 785
            .|||...|.|||:||||||||||||||||:|||:::.|:||||..|....|..:|||||:|:|||
  Fly  1671 GAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPE 1735

  Fly   786 ILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVR 850
            |::||.|..:||||:.||||||||.|:|||  :|..       ||.||..|..:....|..:|..
  Fly  1736 IIKGEKYNQNVDWWSFGVLLYEMLIGQSPF--SGCD-------EDELFWSICNEIPWFPVYISAE 1791

  Fly   851 AASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFP 915
            |..:|||.|.|:...|:|.....| .||..|.||:.:||.|||::|:.|||||::....|...|.
  Fly  1792 ATGILKGLLEKDYTKRIGSQYSPA-GDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFD 1855

  Fly   916 PEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949
            ..||.|.|:|||.|..::.::||.:|.||.|.||
  Fly  1856 RVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	4/51 (8%)
		S_TKc	616..884	CDD:214567	132/267 (49%)
		STKc_aPKC	620..947	CDD:270740	159/326 (49%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	132/267 (49%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	160/328 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000