DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and Prkce

DIOPT Version :10

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_058867.2 Gene:Prkce / 29340 RGDID:61925 Length:737 Species:Rattus norvegicus


Alignment Length:609 Identity:232/609 - (38%)
Similarity:320/609 - (52%) Gaps:144/609 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   475 DGEDRSI-------YRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWG-LGRQGFKCIQC 531
            |.|:|..       .|:||.| |::::||||.|.|....:..:|::|:|.||| :|:||::|..|
  Rat   141 DNEERVFRERMRPRKRQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVC 204

  Fly   532 KLLVHKKCHKLVQKHCT-----DQPEPL------------------------------------- 554
            ..:|||:||:|:...|.     :.|:.:                                     
  Rat   205 TCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQ 269

  Fly   555 ----------VKERAEESSDP-----------IPVPLPPLP---------YEAMSGGAEACE--- 586
                      |..|.|.:..|           :...|...|         .:.::.|||:.:   
  Rat   270 GLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLAAGAESPQPAS 334

  Fly   587 ----THDHAHIVAPPPPED-----------------------------------PLEPGTQRQ-- 610
                :.|.....||..|.|                                   |.|.|..||  
  Rat   335 GNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSSTDGQLASPGENGEVRQGQ 399

  Fly   611 ---YSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETAS 672
               ..|::|..|:|:|:||:.||::.||:....:||:||:||.::..|:|:|...|||.:...|.
  Rat   400 AKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALAR 464

  Fly   673 NHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGII 737
            .||:|..|:.||||..|||||:|:|.|||||:.:||.|:..|..:||||||::.||.|||:.|:|
  Rat   465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529

  Fly   738 YRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 802
            ||||||||:|||.|||.||.|:|||||||..|.||:||||||:|||||||:..:||.||||||||
  Rat   530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALG 594

  Fly   803 VLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRL 867
            ||:|||:||:.||         :.:.||.||:.||...:..|..||..|.|:||.|:.|||..||
  Rat   595 VLMYEMMAGQPPF---------EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRL 650

  Fly   868 GC----HRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPD 928
            ||    :.|.|   |..|||||.:||.|||:|::.||||||:.:.||:.||..:||.|...||..
  Rat   651 GCVAAQNGEDA---IKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLV 712

  Fly   929 DDHVIDNIDQSEFEGFEYVNPLLM 952
            |:.::..|:|.||:||.|....||
  Rat   713 DEAIVKQINQEEFKGFSYFGEDLM 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_aPKC 496..550 CDD:410344 23/59 (39%)
STKc_aPKC 620..947 CDD:270740 174/330 (53%)
PrkceNP_058867.2 C2_PKC_epsilon 3..135 CDD:175981
C1_nPKC_epsilon-like_rpt1 161..224 CDD:410385 26/63 (41%)
Interaction with actin. /evidence=ECO:0000250 223..228 0/4 (0%)
C1_nPKC_epsilon-like_rpt2 241..295 CDD:410388 4/53 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..356 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..398 4/28 (14%)
STKc_nPKC_epsilon 412..732 CDD:270743 175/331 (53%)
Blue background indicates that the domain is not in the aligned region.

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