DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and Prkcz

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	XP_038965237.1	Gene:	Prkcz / 25522	RGDID:	3399	Length:	605	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	341/548 - (62%)
Similarity:	408/548 - (74%)	Gaps:	50/548 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 LQSEEEIEPAYAT------------VFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQ 501
            :.|:.|:|.|:..            |||::|:.||:.|.|||:|||||||||||||||.|||:||
  Rat    70 VSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQ 134

  Fly   502 AKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC---TDQPEPLVKERAEESS 563
            ||||||||:|..|.:|||||.|||::||.|||||||:||.||...|   .|...|..:...::.:
  Rat   135 AKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKN 199

  Fly   564 DPIPVP----------------LPPLPYEAMSGGAEACETHDHAHIVAPPPPED--PLEPGT--- 607
            |.:.:|                ..|:.|.:.|      ..||:    .....||  |:..|.
  Rat   200 DGVDLPSEETDGIALHSTWCATARPVAYISSS------RKHDN----IKDDSEDLKPVIDGVDGI 254

  Fly   608 --QRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFET 670
              .:...|.||:||||||||||||||:|.|::..:||||||:||.||.||||||||||||||||.
  Rat   255 KISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 319

  Fly   671 ASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKG 735
            ||::||||||||||||.||||.|||:|.|||||:||||||:|||||||||||||.:|||||||:|
  Rat   320 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG 384

  Fly   736 IIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWA 800
            ||||||||||||||.:||||||||||||||:.|||||||||||||||||||||||:|||||||||
  Rat   385 IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWA 449

  Fly   801 LGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPAD 865
            ||||::||:|||||||:  .::|||.|||||||||||||.|||||.|||:|:.||||||||:|.:
  Rat   450 LGVLMFEMMAGRSPFDI--ITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKE 512

  Fly   866 RLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDD 930
            ||||..::.|.||.||.||:::||:|||:||..|||:|::..|..|.||..:||.|.|||||||:
  Rat   513 RLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDE 577

  Fly   931 HVIDNIDQSEFEGFEYVNPLLMSLEDCV 958
            .||..|||||||||||:||||:|.|:.|
  Rat   578 DVIKRIDQSEFEGFEYINPLLLSAEESV 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	35/54 (65%)
		S_TKc	616..884	CDD:214567	213/267 (80%)
		STKc_aPKC	620..947	CDD:270740	249/326 (76%)
Prkcz	XP_038965237.1	PB1_aPKC	16..98	CDD:99725	6/27 (22%)
		C1_aPKC_zeta	129..183	CDD:410448	37/53 (70%)
		STKc_aPKC_zeta	249..605	CDD:270768	262/357 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	483	1.000	Domainoid score	I386
eggNOG	1	0.900	-	-		E2759_KOG0695
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	831	1.000	Inparanoid score	I427
OMA	1	1.010	-	-		QHG45540
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003559
OrthoInspector	1	1.000	-	-		otm44387
orthoMCL	1	0.900	-	-		OOG6_104397
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2434
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870