DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and pck2

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_595950.1	Gene:	pck2 / 2539649	PomBaseID:	SPBC12D12.04c	Length:	1016	Species:	Schizosaccharomyces pombe

Alignment Length:	758	Identity:	220/758 - (29%)
Similarity:	332/758 - (43%)	Gaps:	207/758 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 SRCHNTNTTTTDDSGGGSSGGGGVPGTMSSASMAVGMPGMLMDY-HHSHHSGSAGSGLNGCGGGS 387
            |..:|.:...:.|....:||...|....|...|  |...:.|:: .|:.......:||.
pombe   332 SALNNISKPESTDRPNTASGNQSVSAWFSLEPM--GQINLTMNFTKHNTRKRPMDAGLG------ 388

  Fly   388 IAGGSIGGRSSVLGTIHNGHGH---HHQQY-----------------------HHECIHYERLPI 426
             ..|:|..|..   ::|..:||   .||.|                       |:.| |.:..|
pombe   389 -RQGAIRQRKE---SVHEVYGHKFLQHQFYQIMRCALCGEFLKNAAGMQCIDCHYTC-HKKCYP- 447

  Fly   427 PVPIPTVPMGVAPSSQQMSQHQLQSEEEIEPAYATVFPNVPQAPGLSCDGEDRSIYRRGARRWRK 491
                ..|...::.||...|..           |..:...:|
pombe   448 ----KVVTKCISKSSDSASSE-----------YEKINHRIP------------------------ 473

  Fly   492 LYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQ-GFKCIQCKLLVHKKCHKLVQKHC---TDQPE 552
                  |.|::.......:|.:| ..|..|||: ..||.:|.:..|.:|..||...|   .:...
pombe   474 ------HHFESHTNIGANWCCHC-GYILPLGRKTARKCTECGITAHAQCVHLVPDFCGMSMEMAN 531

  Fly   553 PLVKE-------------------------RAEESS------------------------DPIPV 568
            .::.|                         :::.||                        ||:|.
pombe   532 RVISEIRTTKIYKAQQHKQKSSHHKHHHHKKSKSSSSKHKENDKASVSITTTTTPSITPADPVPT 596

  Fly   569 PLPPLPYEAM------SGGAEACETHDH----------------AHIVAPPPPEDPLE-----PG 606
            ...||..|.:      :|..|.....|:                |..:..||..|.::     |.
pombe   597 SPKPLAIEPVKRKPVHAGNLEVTSVSDNKLGATVQVVEQKVDDKADALTKPPSLDAVKEPIPVPS 661

  Fly   607 TQ------------RQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDID 659
            .:            ::..|.||..:.|:|:|::.||::.||:..:::||:||:||..:.::::::
pombe   662 VETSVVAQDLTHKAKRIGLEDFTFLSVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVE 726

  Fly   660 WVQTEKHVFETAS--NHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAA 722
            ..::||.||..|:  .|||||.|||||||.:|::||::||.|||||.|:| |.:.....|:||||
pombe   727 STKSEKRVFLVANRERHPFLVNLHSCFQTETRIYFVMDFVSGGDLMLHIQ-QEQFSRRRAQFYAA 790

  Fly   723 EISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEIL 787
            |:.|||.:.|:.|||||||||||:||..:||:|:.|||:|||.:...:||:||||||.::|||||
pombe   791 EVCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMWHDNTTATFCGTPEFMAPEIL 855

  Fly   788 RGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEK----TIRIPRSLS 848
            ..:.|..||||||.|||:|:||.|:|||      ...|   |:.:|..||..    .|.:||.
pombe   856 LEQQYTRSVDWWAFGVLIYQMLLGQSPF------RGED---EEEIFDAILSDEPLYPIHMPRD-- 909

  Fly   849 VRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLAN 913
              :.|:|:..|.::|..|||.....| .|:::||||.|::|:.:..|:..||:.|.|:|..|...
pombe   910 --SVSILQQLLTRDPKKRLGSGPNDA-EDVMTHPFFSNINWDDIYHKRTQPPYIPSLNSPTDTKY 971

  Fly   914 FPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLED 956
            |..|||.|...|||.:. ::....|..||||.|      |.||
pombe   972 FDEEFTRELPVLTPVNS-ILTKEMQQHFEGFSY------SCED 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	16/55 (29%)
		S_TKc	616..884	CDD:214567	125/273 (46%)
		STKc_aPKC	620..947	CDD:270740	148/332 (45%)
pck2	NP_595950.1	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1_PKC-like_2_fungi	115..186	CDD:212010
		C2_fungal_Pkc1p	213..320	CDD:176071
		C1_1	406..454	CDD:278556	9/53 (17%)
		C1_1	474..526	CDD:278556	16/52 (31%)
		S_TKc	683..942	CDD:214567	125/273 (46%)
		STKc_PKC	688..1003	CDD:270722	148/330 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010