DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and gad8

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_588010.1	Gene:	gad8 / 2539206	PomBaseID:	SPCC24B10.07	Length:	569	Species:	Schizosaccharomyces pombe

Alignment Length:	354	Identity:	143/354 - (40%)
Similarity:	211/354 - (59%)	Gaps:	15/354 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   604 EPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVF 668
            :|......:::.|||::|:|:||:.||:.|..|.|.||||:|.:|||.:....::|....|:.|.
pombe   218 KPNQSTPLTIDAFELLKVVGKGSFGKVMQVRKRDTSRIYALKTMKKAHIVSRSEVDHTLAERTVL 282

  Fly   669 ETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHE 733
            ... |:||:|.|...||:|.:|:.|:.||.||:|.:|:||:.......|:||.||:.:||..|||
pombe   283 AQV-NNPFIVPLKFSFQSPGKLYLVLAFVNGGELFHHLQREGCFDTYRAKFYIAELLVALECLHE 346

  Fly   734 KGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDW 798
            ..:||||||.:|:|||:.|||.|.|:|:||..:...|.|:||||||.|:|||:|.|..|...|||
pombe   347 FNVIYRDLKPENILLDYTGHIALCDFGLCKLNMAKTDRTNTFCGTPEYLAPELLLGHGYTKVVDW 411

  Fly   799 WALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNP 863
            |.||||||||:.|..||        .|:|..: :::.||:..:|.|.::..:|..:|.|.|.:.|
pombe   412 WTLGVLLYEMITGLPPF--------YDENINE-MYRKILQDPLRFPDNIDEKAKDLLSGLLTRAP 467

  Fly   864 ADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGE-AVQLTP 927
            ..|||   .....:|.:||||.::||:.|..|::.|||||.::|..|.:||..|||.| .:....
pombe   468 EKRLG---SGGAQEIKNHPFFDDIDWKKLCAKKIQPPFKPSVESAIDTSNFDSEFTSEIPMDSVV 529

  Fly   928 DDDHVIDNIDQSEFEGFEYVNPLLMSLED 956
            .|.|:.:.: |..|..:.|..|..:...|
pombe   530 ADSHLSETV-QQRFANWSYQRPTTIDTSD 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556
		S_TKc	616..884	CDD:214567	116/267 (43%)
		STKc_aPKC	620..947	CDD:270740	136/327 (42%)
gad8	NP_588010.1	YPK1_N_like	66..225	CDD:212165	1/6 (17%)
		PTZ00263	214..545	CDD:140289	140/340 (41%)
		STKc_YPK1_like	235..547	CDD:270737	136/325 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910