Protein Alignment aPKC and Prkca

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: XP_038941139.1
• Gene: Prkca / 24680
• RGDID: 3395
• Length: 722
• Species: Rattus norvegicus
• Alignment Length: 701
• Identity: 231/701 - (32%)
• Similarity: 302/701 - (43%)
• Gaps: 245/701 - (34%)

  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 547
            |:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|..|..:|||:||:.|...|
  Rat    22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86

  Fly   548 --------TDQPEP--------------------------------------------------- 553
                    ||.|..
  Rat    87 PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLC 151

  Fly   554 ------------LVKERAEES-------------------SDP------IPVP------------ 569
                        |..|..:|.                   |||      ||.|
  Rat   152 GMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIR 216

  Fly   570 ----------------------------------------------------LP----------- 571
                                                                :|
  Rat   217 STLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQE 281

  Fly   572 -------PLPYEAMSGGAEACETHDHAHIVAP------PPPEDPLEPGTQ-RQYSLNDFELIRVI 622
                   |:|.....|..|..:..:.|.: .|      .|.||..:|... .:..|.||..:.|:
  Rat   282 EGEYYNVPIPEGDEEGNVELRQKFEKAKL-GPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVL 345

  Fly   623 GRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTP 687
            |:||:.||::.:.:.|..:||:|::||.:|..|:|::....||.|.......|||..|||||||.
  Rat   346 GKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTV 410

  Fly   688 SRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEG 752
            .||:||:|:|.|||||||:|:..:..|..|.|||||||:.|.|||::||||||||||||:||.||
  Rat   411 DRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEG 475

  Fly   753 HIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDL 817
            |||:.|:|||||.:..|.||.||||||:||||||:..:.||.||||||.||||||||||:.||
  Rat   476 HIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-- 538

  Fly   818 AGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHP 882
                   |...||.|||.|:|..:..|:|||..|.|:.||.:.|:||.||||..|.. .|:..|.
  Rat   539 -------DGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGE-RDVREHA 595

  Fly   883 FFKNMDWELLERKQVTPPFKPRLDSDRDL------------------------------------ 911
            ||:.:|||.||.:::.|||||::....::
  Rat   596 FFRRIDWEKLENREIQPPFKPKVQCTAEVRGFTAFSTQLFLILDISNSSPLSVLILQNFCTKMHW 660

  Fly   912 -------------ANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949
                         .||...||.....|||.|..||.|||||:||||.||||
  Rat   661 LQWASRPSCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	25/61 (41%)
		STKc_aPKC	620..947	CDD:270740	172/375 (46%)
Prkca	XP_038941139.1	C1_cPKC_rpt1	35..92	CDD:410383	24/56 (43%)
		C1_cPKC_rpt2	102..155	CDD:410386	0/52 (0%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	10/129 (8%)
		Protein Kinases, catalytic domain	328..718	CDD:473864	179/394 (45%)